Giant proteins play essential cellular roles but remain structurally challenging. Recent advances in structure determination and modeling reveal that tandem repeats are widespread in large proteins, providing modularity, adaptability, and multifunctionality. Examples including apolipoprotein B100, teneurins, and ryanodine receptors illustrate how repetition drives structural flexibility, regulatory precision, and evolutionary innovation.
Tandem repeats matter for the functional versatility of giant proteins
Osmanli Z.;Monzon A. M.;Tosatto S. C. E.
2026
Abstract
Giant proteins play essential cellular roles but remain structurally challenging. Recent advances in structure determination and modeling reveal that tandem repeats are widespread in large proteins, providing modularity, adaptability, and multifunctionality. Examples including apolipoprotein B100, teneurins, and ryanodine receptors illustrate how repetition drives structural flexibility, regulatory precision, and evolutionary innovation.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
