Deformable Vesicles with Edge Activators for the Transdermal Delivery of Non-Psychoactive Cannabinoids

Background: Transdermal delivery of highly lipophilic molecules is challenging due to the strong barrier function of the skin. Vesicles with penetration enhancers are safe and efficient systems that could improve the transdermal delivery of non-psychoactive cannabinoids such as cannabidiol and desoxy-cannabidiol. In the last decades, research interest in desoxy-cannabidiol as a potent drug with anti-nociceptive properties has risen. Still, its scarce market availability poses a limit for both...

To mob or not to mob? No... To stress or not to stress!

An Online Single-Ended Traveling Waves Fault Detection Algorithm for High-Voltage Multi-Branch Overhead Lines

This paper proposes a novel single-ended traveling wave-based fault location method for unearthed overhead lines with a complex topology. The low fault current magnitudes of a phase-to-ground fault in unearthed sub-transmission networks make ineffective the operation of the impedance-based protection. The proposed method decouples the dependence of the traveling waves propagation modes on the speed propagation of the line, to release the analysis of a multi-branched non-homogeneous line by me...

Dynamic Power Flow Modeling Primary and Secondary Frequency Regulations

In power systems, the steady-state operations following any disturbance can be assessed by means of time-domain simulations, which consider the dynamic of the system without simplifying hypotheses. This paper proposes a formulation of the power flow problem with distributed slack bus model able to determine the steady-state impact on frequency and generation set-points of primary and secondary frequency regulation. This is done by deriving the real power balance expressions (including power l...