Recent advances in tissue engineering have drawn scientists to test the possibility of tooth engineering and regeneration. Tooth regeneration is normally referred to as the regeneration of the entire tooth or root that can be integrated into the jaw bone. This technology is still at its infancy and when it matures, it may be used to restore missing teeth and replace artificial dental implants When the tooth is damaged but still in a reparable condition, regeneration of parts of the tooth structure can prevent or delay the loss of the whole tooth. To engineer and regenerate a whole tooth, the cell source, tissue engineering strategies and specific scaffolds needed to be correct choose. Indeed, for example, to repair partly lost tooth tissues such as PDL, dentin, and pulp, one or two particular types of dental stem cells may be sufficient to fulfill the need. In light of such considerations, aim of the present chapter is to define the main strategies to isolate dental pulp stem cells, their characterisation and differentiation, tissue enngineering strategies and clinical applications for the creation of artificial tissue useful in odontoiatric field.
Dental pulp stem cells and tissue engineering strategies for clinical application on odontoiatric field
BRESSAN, ERIBERTO;SIVOLELLA, STEFANO;BRUNELLO G;FERRONI, LETIZIA;GARDIN, CHIARA;ZAVAN, BARBARA
2011
Abstract
Recent advances in tissue engineering have drawn scientists to test the possibility of tooth engineering and regeneration. Tooth regeneration is normally referred to as the regeneration of the entire tooth or root that can be integrated into the jaw bone. This technology is still at its infancy and when it matures, it may be used to restore missing teeth and replace artificial dental implants When the tooth is damaged but still in a reparable condition, regeneration of parts of the tooth structure can prevent or delay the loss of the whole tooth. To engineer and regenerate a whole tooth, the cell source, tissue engineering strategies and specific scaffolds needed to be correct choose. Indeed, for example, to repair partly lost tooth tissues such as PDL, dentin, and pulp, one or two particular types of dental stem cells may be sufficient to fulfill the need. In light of such considerations, aim of the present chapter is to define the main strategies to isolate dental pulp stem cells, their characterisation and differentiation, tissue enngineering strategies and clinical applications for the creation of artificial tissue useful in odontoiatric field.
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