Case 10: Creutzfeldt–Jakob Disease

A 76-year-old obese male presented for cognitive decline, mainly with deficits in the verbal domain (anomia and verbal perseverations), drowsiness, mild camptocormic posture with left arm bradykinesia, and recurrent falls. In the clinical suspect of a primary progressive aphasia with parkinsonism, the patient was referred to a [18F]FDG PET/MR that showed moderate cortical hypometabolism in the left temporal pole extending to the homolateral insular region. A co-acquired high-resolution diffus...

Case 7: Typical AD with Discordant Biomarkers

A 59-year-old female with a clinical history (4 years) of mild cognitive impairment with long-term (episodic and autobiographic) and short-term memory deficits worsened in the last 2 years. A [18F]FDG PET/MR showed a pattern that could be associated with a diagnosis within the Alzheimer’s continuum; however, a CSF analysis was negative for cerebral amyloidosis. [18F]Florbetaben (90–110 min after injection) amyloid scan revealed diffuse bilateral cortical and subcortical uptake of the radiopha...

Case 9: Frontotemporal Dementia, Behavioral Variant, Mimicker

A 54-year-old male patient was referred to the emergency department for a rapid progression of lethargic state and apathetic behavior. Assessment in the following days revealed apathic behavior and reduced verbal fluency and severe obstructive sleep apnea syndrome. In the suspect of frontotemporal dementia and to rule out possible neoplastic conditions, the patient was referred to a whole-body and brain [18F]FDG PET/MR. Brain [18F]FDG PET/MR revealed a clear hypometabolism of the frontal cort...

Case 31: Limbic Encephalitis