PALUMBO, MANLIO
 Distribuzione geografica
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Continente #
NA - Nord America 24.615
AS - Asia 11.691
EU - Europa 5.099
AF - Africa 2.245
SA - Sud America 1.945
OC - Oceania 219
Continente sconosciuto - Info sul continente non disponibili 198
Totale 46.012
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Nazione #
US - Stati Uniti d'America 23.449
SG - Singapore 3.735
CN - Cina 2.012
VN - Vietnam 1.472
HK - Hong Kong 1.219
BR - Brasile 1.108
IT - Italia 565
FI - Finlandia 557
FR - Francia 537
DE - Germania 451
BD - Bangladesh 356
IN - India 355
UA - Ucraina 289
SE - Svezia 264
PL - Polonia 254
RU - Federazione Russa 250
IQ - Iraq 233
GB - Regno Unito 206
AR - Argentina 173
TR - Turchia 155
NL - Olanda 152
PH - Filippine 142
JP - Giappone 128
PK - Pakistan 118
ID - Indonesia 113
CO - Colombia 110
SA - Arabia Saudita 107
UZ - Uzbekistan 107
ZA - Sudafrica 102
IE - Irlanda 100
MX - Messico 100
CA - Canada 94
MY - Malesia 94
ES - Italia 87
EC - Ecuador 85
VE - Venezuela 85
TH - Thailandia 83
JO - Giordania 82
CI - Costa d'Avorio 79
PY - Paraguay 78
KE - Kenya 77
AO - Angola 73
JM - Giamaica 73
EG - Egitto 72
AT - Austria 71
MA - Marocco 71
CR - Costa Rica 70
LB - Libano 70
PE - Perù 70
AZ - Azerbaigian 68
TN - Tunisia 68
DK - Danimarca 66
TT - Trinidad e Tobago 66
KR - Corea 65
LY - Libia 65
PS - Palestinian Territory 65
BJ - Benin 64
IS - Islanda 63
NI - Nicaragua 63
PA - Panama 63
BY - Bielorussia 62
CL - Cile 62
DZ - Algeria 62
DO - Repubblica Dominicana 61
GM - Gambi 61
RS - Serbia 61
UY - Uruguay 61
AE - Emirati Arabi Uniti 60
AL - Albania 60
KZ - Kazakistan 60
ML - Mali 60
GA - Gabon 59
GF - Guiana Francese 59
KH - Cambogia 59
LV - Lettonia 59
SI - Slovenia 59
SO - Somalia 59
CH - Svizzera 58
CM - Camerun 58
CV - Capo Verde 58
CZ - Repubblica Ceca 58
IR - Iran 58
NP - Nepal 58
PT - Portogallo 58
BE - Belgio 57
ET - Etiopia 57
TW - Taiwan 57
KG - Kirghizistan 56
AU - Australia 55
HN - Honduras 55
GE - Georgia 54
HU - Ungheria 54
TJ - Tagikistan 54
LA - Repubblica Popolare Democratica del Laos 53
MZ - Mozambico 53
MG - Madagascar 52
BF - Burkina Faso 51
BG - Bulgaria 51
CW - ???statistics.table.value.countryCode.CW??? 51
HR - Croazia 51
Totale 43.340
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Città #
Fairfield 2.558
Singapore 2.291
Ashburn 2.290
Woodbridge 2.252
San Jose 1.796
Ann Arbor 1.592
Houston 1.525
Chandler 1.218
Jacksonville 1.206
Hong Kong 1.101
Wilmington 1.025
Seattle 967
Cambridge 920
Santa Clara 494
Princeton 468
Boardman 427
Ho Chi Minh City 400
Beijing 376
Hanoi 344
San Diego 287
Lauterbourg 264
Los Angeles 256
Roxbury 238
Helsinki 217
Nanjing 209
Bytom 197
Medford 175
Dong Ket 173
Des Moines 116
New York 114
Baghdad 90
Tashkent 89
Guangzhou 85
São Paulo 82
Chicago 80
Amman 78
Abidjan 71
Padova 70
Dublin 67
Tokyo 67
Luanda 63
Baku 62
Da Nang 62
Milan 62
Hebei 61
Managua 61
Norwalk 61
Shenyang 61
Panama City 60
Cotonou 58
Council Bluffs 57
Libreville 57
Nairobi 57
Bamako 54
Phnom Penh 54
San José 54
Buffalo 53
Montevideo 52
Nanchang 52
Tianjin 51
Changsha 50
Haiphong 50
Dallas 49
Dushanbe 49
Vienna 49
Bishkek 48
Noumea 48
Reykjavik 48
Antananarivo 47
Cayenne 47
Dakar 47
Praia 47
Ulan Bator 47
Nouakchott 46
Rome 46
Addis Ababa 45
Bridgetown 45
Kampala 45
Vientiane 45
Castries 44
Conakry 44
Dar es Salaam 44
Harare 44
Kigali 44
Lima 44
London 44
Minsk 44
Riga 44
Havana 43
Kingston 43
Kuala Lumpur 42
Atlanta 41
Djibouti 41
Frankfurt am Main 41
Johannesburg 40
Kinshasa 40
Maputo 40
Niamey 40
Jeddah 39
Lusaka 39
Totale 29.210
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Nome #
Interaction of calcium ions with α-elastin: an equilibrium dialysis, circular dichroism, and microcalorimetric study 355
The cellular protein nucleolin preferentially binds long-looped G-quadruplex nucleic acids 302
Screening of candidate G-quadruplex ligands for the human c-KIT promotorial region and their effects in multiple in-vitro models 277
The 6-Aminoquinolone WC5 Inhibits Human Cytomegalovirus Replication at an Early Stage by Interfering with the Transactivating Activity of Viral Immediate-Early 2 Protein 270
Reactivity of Clerocidin towards adenine: implications for base modulated DNA damage 268
Assessment of gene promoter G-quadruplex binding and modulation by a naphthalene diimide derivative in tumor cells 264
A Dynamic G-Quadruplex Region Regulates the HIV-1 Long Terminal Repeat Promoter 262
Novel Ametantrone-Amsacrine Related Hybrids as Topoisomerase II? Poisons and Cytotoxic Agents 258
Virtual Cross-Linking of the Active Nemorubicin Metabolite PNU-159682 to Double-Stranded DNA 254
G-rich sequences within proto-oncogene KIT promoter region as targets for anticancer therapy. 246
Molecular Basis for Differential Recognition of G-Quadruplex versus Double-Helix DNA by Bis-Phenanthroline Metal Complexes 245
Benzo- and tetrahydrobenzo-psoralen congeners: DNA binding and photobiological properties 243
Rational Design, Synthesis, and DNA Binding Properties of Novel Sequence-Selective Peptidyl Congeners of Ametantrone 242
G-quadruplexes in human promoters: A challenge for therapeutic applications 242
Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: In vitro antiproliferative activity and molecular mechanism(s) of action 239
6-aminoquinolones as new potential anti-HIV agents 237
Impairment of c-kit expression in human cancer cell lines by a novel pharmacophoric unit selected for the recognition of the proto-oncogene KIT promotorial region. 237
Aminoacyl-analogues of Mitoxantrone as novel DNA-damaging cytotoxic agents 234
The topoisomerase II poison clerocidin alkylates non-paired guanines of DNA: implications for the irreversible stimulation of DNA cleavage 233
Sequencing and G-quadruplex folding of the canine proto-oncogene KIT promoter region: might dog be used as a model for human disease? 232
Aza-isoindolo and isoindolo-azaquinoxaline derivatives with antiproliferative activity 232
New anti-human immunodeficiency type 1 6-aminoquinolones: mechanism of action 230
Quinone methides tethered to naphthalene diimides as selective G-quadruplex alkylating agents 229
Effects of common buffer systems on drug activity: the case of clerocidin 227
A viable route to designable chiral macromolecular supports: Implications for supported metal catalysis 227
Biologically relevant Cu2+ complexes with a tridentate phenanthroline analogue: structural properties and DNA damage 225
A novel 9-aza-anthrapyrazole effective against human prostatic carcinoma xenografts 225
Sequence selectivity of Topoisomerase II DNA cleavage stimulated by Mitoxantrone derivatives: relationships with drug DNA binding and cellular effects 224
Clerocidin alkylates DNA through its epoxide function: evidence for a fine tuned mechanism of action 220
Targeting canine kit promoter by candidate DNA G-quadruplex ligands 218
Novel pyrrolo [3,2-f]quinolines: synthesis and antiproliferative activity 215
Analysis of topoisomerase (TOP) expression in peripheral blood mononuclear cell (PBMCs) from patients (PTS) undergoing chemotherapy (CHT) for solid tumors(ST) 215
Relevance of DNA binding to the mechanism of anti-herpesvirus activity of benzhydrazone 214
BINOL-amino acid conjugates as triggerable carriers of DNA-targeted potent photocytotoxic agents 212
Formation of a Unique Cluster of G-Quadruplex Structures in the HIV-1 nef Coding Region: Implications for Antiviral Activity 212
Sequence specificity of psoralen photobinding to DNA: a quantitative approach 210
Involvement of p53 in specific anti-neuroectodermal tumor activity of aloe-emodin 210
2-phenylquinolones as inhibitors of the HIV-1 Tat/TAR interaction. 209
Nucleic acid aptamers based on the G-quadruplex structure: therapeutic and diagnostic potential 207
Synthesis and biological activity of new quinolone derivatives 206
Targeting canine c-KIT promoter by a candidate DNA G-quadruplex ligand 206
Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives. 205
DNA-Interactive Anticancer Aza-Anthrapyrazoles: Biophysical and Biochemical Studies Relevant to the Mechanism of Action 203
Benzofurocoumarins: new monofunctional DNA-photobinding agents 203
Antiviral 6-amino-quinolones: Molecular basis for potency and selectivity. 203
Ni2+ and Cu2+ complexes of a phenanthroline-based ligand bind to G-quadruplexes at non-overlapping sites 202
BINOL quinone methides as bis-alkylating and DNA cross-linking agents 201
Inflammatory cytokine expression following the use of bipolar electrocoagulation, ultracision harmonic scalpel and cold knife biopsy 200
DNA gyrase requires DNA for effective two-site coordination of divalent metal ions: further insight into the mechanism of enzyme action 198
Pyrrolocoumarin derivatives: DNA-binding properties 198
Quinone Methide Generation via Photoinduced Electron Transfer 197
The effects of metal ions on the structure and stability of the DNA gyrase B protein 197
Amido analogs of mitoxantrone: physico-chemical properties, molecular modeling, cellular effects and antineoplastic potential 197
Dinuclear Zn2+ complexes of synthetic heptapeptides as artificial nucleases 196
Aminoacyl-anthraquinone conjugates as telomerase inhibitors: synthesis, biophysical and biological evaluation 195
Antiviral properties of quinolone-based drugs. 195
Bis-phenanthroline derivatives as suitable scaffolds for effective G-quadruplex recognition 193
DNA-binding preferences of bisantrene analogues: Relevance to the sequence specificity of drug-mediated topoisomerase II poisoning 193
Methylfuroquinolinones: new furocoumarin isosters as potential photoreagents toward DNA. 192
Naphthalene diimide scaffolds with dual reversible and covalent interaction properties towards G-quadruplex 192
Characterization of the promoter region of the proto-oncogene c-kit in canine mast cell tumour 192
On the mechanism of action of quinolone drugs 190
Synthesis and photobiological properties of 4- hydroxymethyl-4'- methylpsoralen derivatives. 190
A Dynamic G-Quadruplex Region Regulates the HIV-1 Long Terminal Repeat Promoter 190
Hot-spot consensus of fluoroquinolone-mediated DNA cleavage by gram-negative and gram-positive type II DNA topoisomerases 189
A G-quadruplex binding compound down-regulates KIT, BCL2 and PDGFRβ expression in human gastric carcinoma cell line 189
Tuning G-quadruplex vs. double stranded DNA recognition in regioisomeric lysyl-peptidyl-anthraquinone conjugates 188
Mapping drug interactions at the covalent topoisomerase II-DNA complex by bisantrene/amsacrine congeners 187
Clerocidin-mediated DNA footprinting discriminates among different G-quadruplex conformations and detects tetraplex folding in a duplex environment 187
Fast atom bombardment mass spectrometry of some pharmacologically relevant anthraquinone derivatives 187
Chromophore-modified antitumor anthracenediones: synthesis, DNA binding and cytotoxic activity of 1,4-bis[(aminoalkil)amino]benzo [g]phthalazine-5,10-diones 186
Effect of chemotherapy on topoisomerase (TOP) expression and activity in colon carcinoma cells 186
Targeting Loop Adenines in G-Quadruplex by a Selective Oxirane 186
Concerted bis-alkylating reactivity of clerocidin towards unpaired cytosine residues in DNA 185
Clerocidin interacts with the cleavage complex of Streptococcus pneumoniae topoisomerase IV to induce selective irreversible DNA damage 184
Highly Improved Electrospray Ionization-Mass Spectrometry Detection of G-Quadruplex-Folded Oligonucleotides and Their Complexes with Small Molecules 184
In vitro Selection of DNA Aptamers that Bind L-Tyrosinamide 184
Effects of Magnesium and related divalent metal ions in topoisomerase structure and function 183
Interaction model for anthracycline activity against DNA topoisomerase II 182
Conformation and Stability of Intramolecular Telomeric G-Quadruplexes: Sequence Effects in the Loops 182
Simocyclinone D8 turns on against Gram-negative bacteria in a clinical setting 180
Tuning the activity of Zn(II) complexes in DNA cleavage: Clues for design of new efficient metallo-hydrolases 180
Quinolone binding to DNA is mediated by magnesium ions 180
Topoisomerase I involvement in schedule-dependent interaction between 5-fluoro-uracil and irinotecan in the treatment of colorectal cancer. 179
Potent 6-desfluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy 179
Effects of Sulfation on Antithrombin-Thrombin/Factor Xa Interactions in Semisynthetic Low-Molecular Weight Heparins 179
Design, Synthesis and Biological Properties of New Bis(acridine-4-carboxamides) as Anticancer Agents 179
Folding versus charge: understanding selective target recognition by the thrombin aptamers 177
Synthesis of 2H,9H-naphtho[2,3-b:7,6-b']dipyran-2,9-diones as potential DNA-reactive agents 177
Telomeric G-quadruplex architecture and interactions with potential drugs 177
Antracyclines: recent developments in their separation and quantitation 175
The effect of the minor groove binding agent DAPI (4', 6-diamidino-2-phenyl-indole) on DNA-directed enzymes: an attempt to explain inhibition of plasmid expression in Escherichia coli 174
Interaction between the cytotoxic drug Clerocidin and DNA: evidence for covalent adduct formation 172
A potentiometric and CD study on the beta-random coil transition of poly-L-tyrosine in aqueous solution. 172
New hydroxy-amido-anthraquinones as potential antineoplastic drugs 172
DNA topoisomerase-targeted drugs 172
Ferric complexes of acetoacetyl derivatives of poly(L-lysine), poly(L-ornithine), and poly(L-diaminobutyric acid). I. Preparation and absorption properties in solution. 171
Alternative approaches to the discovery and development of telomerase-targeted anticancer drugs 170
Heterocyclic Dications as a New Class of Telomeric G-Quadruplex Targeting Agents 170
Remarkable lack of biological activity exhibited by a dna-reactive and water-soluble cis-bis(phosphino) platinum(II) complex 170
Totale 20.709
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Categoria #
all - tutte 128.452
article - articoli 113.351
book - libri 648
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 963
selected - selezionate 0
volume - volumi 2.824
Totale 246.238
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20223.578 0 474 535 245 131 143 152 400 157 62 426 853
2022/20232.511 596 264 47 292 409 325 5 151 285 5 97 35
2023/20241.030 46 167 135 66 91 108 51 31 25 26 149 135
2024/20254.991 11 287 302 188 805 131 195 321 534 148 806 1.263
2025/202619.944 434 1.787 3.033 3.476 1.562 837 2.390 1.851 2.286 1.214 565 509
2026/2027880 622 258 0 0 0 0 0 0 0 0 0 0
Totale 46.012