The action of solar radiation on the concentration of the ethanol metabolite Ethylglucuronide (EtG) in 40 hair samples of non-abstinent subjects was investigated. Hair samples of different colors were analyzed before and after irradiation with artificial sunlight under a light dose corresponding to three months of sun exposure. After irradiation, an increase of EtG concentration was detected in 55% of the samples ranging from 5 % to 141 %. In 16 cases, a concentration reduction ranging from -2% to -74% was observed. The measure of the level of pyrrole-tricarboxylic acid (PTCA), a marker of eumelanin oxidation, demonstrated the largest increase in oxidation in light brown hair where the greatest degradation of EtG was observed after irradiation. However, the rise of PTCA in all hair tested was accompanied by an increase in EtG concentration in 8/10 samples and by a decrease in 2/10, suggesting no correlation between the two markers. To verify if hair structure was modified by light, Scanning Electron Microscopy (SEM) analysis was performed on irradiated hair of different colors and compared with the dark samples. SEM revealed modification of hair structure in all samples showing partial shaft exfoliation and reduction of hair thickness under the treatment with solar radiation.

Does Eumelanin Oxidation Play A Role on the Photostability of Ethyl Glucuronide in Hair Exposed to Simulated Solar Radiation?

Giorgia Miolo;Valerio Causin;Susanna Vogliardi;Donata Favretto.
2021

Abstract

The action of solar radiation on the concentration of the ethanol metabolite Ethylglucuronide (EtG) in 40 hair samples of non-abstinent subjects was investigated. Hair samples of different colors were analyzed before and after irradiation with artificial sunlight under a light dose corresponding to three months of sun exposure. After irradiation, an increase of EtG concentration was detected in 55% of the samples ranging from 5 % to 141 %. In 16 cases, a concentration reduction ranging from -2% to -74% was observed. The measure of the level of pyrrole-tricarboxylic acid (PTCA), a marker of eumelanin oxidation, demonstrated the largest increase in oxidation in light brown hair where the greatest degradation of EtG was observed after irradiation. However, the rise of PTCA in all hair tested was accompanied by an increase in EtG concentration in 8/10 samples and by a decrease in 2/10, suggesting no correlation between the two markers. To verify if hair structure was modified by light, Scanning Electron Microscopy (SEM) analysis was performed on irradiated hair of different colors and compared with the dark samples. SEM revealed modification of hair structure in all samples showing partial shaft exfoliation and reduction of hair thickness under the treatment with solar radiation.
File in questo prodotto:
File Dimensione Formato  
bkaa150.pdf

non disponibili

Tipologia: Published (publisher's version)
Licenza: Accesso privato - non pubblico
Dimensione 3.04 MB
Formato Adobe PDF
3.04 MB Adobe PDF Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/3353770
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 2
  • OpenAlex ND
social impact