Model-based design of experiments is exploited to design informative experiments for the identification of heat transfer coefficients in a primary-drying model for the lyophilisation of vaccines. The proposed methodology allows one to design fast and cost-effective experiments for product transfer in different pieces of equipment. The effectiveness of the methodology is tested for different freeze drying units.
Model-based design of experiments to enable fast product transfer across freeze-drying units.
Riccardo De-Luca;Gabriele Bano;Fabrizio Bezzo;Massimiliano Barolo
2019
Abstract
Model-based design of experiments is exploited to design informative experiments for the identification of heat transfer coefficients in a primary-drying model for the lyophilisation of vaccines. The proposed methodology allows one to design fast and cost-effective experiments for product transfer in different pieces of equipment. The effectiveness of the methodology is tested for different freeze drying units.
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