04 CONTRIBUTO IN ATTO DI CONVEGNO

04 CONTRIBUTO IN ATTO DI CONVEGNO: [55800] Home page macrotipologia

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Intervento di riduzione del danno per fumatori con gravi disturbi psichiatrici: uno studio qualitativo sulle esperienze con la sigaretta elettronica

Modeling metabolic overload effects in bacterial growth rate in synthetic biology

Modeling growth in bacterial cells is a major issue in systems and synthetic biology. Despite several growth rate functions are proposed in literature, most of them focus on nutrients composition, without explicitly counting for possible perturbation provided by the expression of recombinant genes, an effect called metabolic load or burden. In this work, some already published growth functions are evaluated, highlighting possible disagreements with the biological knowledge, which allow to rej...

Network-GIANT: Fully Distributed Newton-Type Optimization via Harmonic Hessian Consensus

This paper considers the problem of distributed multi-agent learning, where the global aim is to minimize a sum of local objective (empirical loss) functions through local optimization and information exchange between neighboring nodes. We introduce a Newton-type fully distributed optimization algorithm, Network-GIANT, which is based on GIANT, a Federated learning algorithm that relies on a central parameter server. Network-GIANT is designed via a combination of gradient-tracking and a Newton...

Uncovering quorum sensing and quenching structural properties: a systems biology approach

Bacteria have the ability to coordinate their behavior in a cell density-dependent manner by using diffusible signal molecules. The mechanism, known as quorum sensing, is a cell-to-cell communication process exploited either by pathogens to regulate the expression of virulence and antimicrobial resistance-related genes and by synthetic biologists to engineer bacterial density-dependent functions. Using a systems biology approach, we developed a novel quorum sensing mathematical model and perf...

Automated control of bioreactors: An hardware-in-the-loop proof of concept test towards an experimental facility

Ensuring controlled environmental conditions during bacterial growth in a bioreactor is often crucial for the success of an experiment or to grant efficiency in an industrial procedure. For instance, in some experiments, temperature, oxygen and pH levels should be kept constant to achieve a good yield. Commercial bioreactors commonly provide proprietary automation systems for the regulation of some of the above mentioned variables, but the possibility to personalize the control algorithm, to ...

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