LKB1 is a key sensor of metabolic stress, including hypoxia and glucose deprivation, two features of the tumor microenvironment exacerbated by antiangiogenic therapy. We investigated the role of LKB1 as potential predictive marker of sensitivity to bevacizumab in advanced non-small cell lung cancer (aNSCLC).
LKB1 expression correlates with increased survival in advanced non-small cell lung cancer patients treated with chemotherapy and bevacizumab
Bonanno, Laura;De Paoli, Angela;Zulato, Elisabetta;CALABRESE, FIORELLA;Favaretto, Adolfo;Santo, Antonio;CICCARESE, FRANCESCO;Bertorelle, Roberta;De Salvo, Gian Luca;AMADORI, ALBERTO;Conte, Pierfranco;Indraccolo, Stefano
2017
Abstract
LKB1 is a key sensor of metabolic stress, including hypoxia and glucose deprivation, two features of the tumor microenvironment exacerbated by antiangiogenic therapy. We investigated the role of LKB1 as potential predictive marker of sensitivity to bevacizumab in advanced non-small cell lung cancer (aNSCLC).
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