The in vitro reconstruction of skin and cartilage by means of hyaluronan (HA)-based 3D scaffolds and their clinical application was studied. Biochemical tests and morphological analyses confirmed that the chondrocytes easily adhered and proliferated onto HA-based scaffolds. Autologous fibroblasts were cultured in fleece scaffolds made from benzyl esters of hyaluronic acid and cultivated for 15 days. The clinical results indicate that Hyalograft C may be a viable therapeutic option for the treatment of acute cartilage lesions.
HA-based materials for soft and hard connective tissues: in vitro reconstruction and clinical applications
CORTIVO, ROBERTA;ZAVAN, BARBARA;BRUN, PAOLA;ABATANGELO, GIOVANNI
2004
Abstract
The in vitro reconstruction of skin and cartilage by means of hyaluronan (HA)-based 3D scaffolds and their clinical application was studied. Biochemical tests and morphological analyses confirmed that the chondrocytes easily adhered and proliferated onto HA-based scaffolds. Autologous fibroblasts were cultured in fleece scaffolds made from benzyl esters of hyaluronic acid and cultivated for 15 days. The clinical results indicate that Hyalograft C may be a viable therapeutic option for the treatment of acute cartilage lesions.File in questo prodotto:
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