A number of new isosters of psoralen, in wich the benzene ring of psoralen is substituted with a pyridine one were synthesized. The synthesis were performed starting from the appropriate hydroxypyranopyridinone on which the furan ring was built. Several derivatives in which an additional cyclohexene or benzene ring is condensed to the furan ring moiety have also been prepared.
Synthesis of azapsoralen derivatives.
CHILIN, ADRIANA;GUIOTTO, ADRIANO
1988
Abstract
A number of new isosters of psoralen, in wich the benzene ring of psoralen is substituted with a pyridine one were synthesized. The synthesis were performed starting from the appropriate hydroxypyranopyridinone on which the furan ring was built. Several derivatives in which an additional cyclohexene or benzene ring is condensed to the furan ring moiety have also been prepared.
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