Malignant gliomas continue to demand the search for improved chemotherapeutic solutions. In this work the results of a preliminary in vitro screening performed on a small library of compounds are disclosed. As a result 2-(2,4-dihydroxyphenyl)-8-hydroxy-1,4-naphthoquinone emerged as a promising therapeutic lead.
8-Hydroxynaphthalene-1,4-dione derivative as novel compound for glioma treatment
ZAGOTTO, GIUSEPPE;REDAELLI, MARCO;D'AVELLA, DOMENICO;COZZA, GIORGIO;DENARO, LUCA;MUCIGNAT, CARLA
2011
Abstract
Malignant gliomas continue to demand the search for improved chemotherapeutic solutions. In this work the results of a preliminary in vitro screening performed on a small library of compounds are disclosed. As a result 2-(2,4-dihydroxyphenyl)-8-hydroxy-1,4-naphthoquinone emerged as a promising therapeutic lead.
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