A series of peptide–peptoid hybrids, containing N-substituted glycines, were synthesized based on the H-Aib-Val-Aib-Glu-Ile- Gln-Leu-Nle-His-Gln-Har-NH2 (Har = Homoarginine) as the parent parathyroid hormone (1–11) analog. The compounds were pharmacologically characterized in their agonistic activity at the parathyroid hormone 1 receptor
Peptide-peptoid hybrids based on(1-11)-parathyroid hormone analogs
CAPORALE, ANDREA;SCHIEVANO, ELISABETTA;PEGGION, EVARISTO
2010
Abstract
A series of peptide–peptoid hybrids, containing N-substituted glycines, were synthesized based on the H-Aib-Val-Aib-Glu-Ile- Gln-Leu-Nle-His-Gln-Har-NH2 (Har = Homoarginine) as the parent parathyroid hormone (1–11) analog. The compounds were pharmacologically characterized in their agonistic activity at the parathyroid hormone 1 receptor
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