The biological activity of a new group of benzopsoralens and tetrahydrobenzopsoralens were investigated. In Ehrlich cells all compounds induced a significant inhibition of DNA synthesis, both after UVA irradiation and in the dark. The presence of a hydroxymethyl group at 4 position is important for the activity in the dark.
Activity of new benzo- and tetrahydrobenzopsoralen derivatives.
BACCICHETTI, FRANCAROSA;CARLASSARE, FRANCESCO;TONIOLO, LUANA;CHILIN, ADRIANA;BORDIN, FRANCO
1993
Abstract
The biological activity of a new group of benzopsoralens and tetrahydrobenzopsoralens were investigated. In Ehrlich cells all compounds induced a significant inhibition of DNA synthesis, both after UVA irradiation and in the dark. The presence of a hydroxymethyl group at 4 position is important for the activity in the dark.
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