HEADACHE SECONDARY TO AN UNUSUAL VALSALVA MANOEUVRE IN A MIGRAINOUS PATIENT WITH CACOSMIA

Transitory global amnesia (TGA) and migraine without aura (MO) are diseases with unclear pathophysiologic mechanisms, but with evidence of comorbidity. We describe twin monozygotic brothers, both presenting episodes of TGA occurring only during attacks of MO. This report supports the hypothesis of a common underlying pathogenetic mechanism, possibly related to the cortical spreading depression (CSD). Furthermore, a common genetic trait in both the diseases or more probably in a particular sub-group of patients could be hypothesized.