MEGGIO, FLAVIO
 Distribuzione geografica
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Continente #
NA - Nord America 9.425
AS - Asia 974
EU - Europa 930
OC - Oceania 7
SA - Sud America 4
Continente sconosciuto - Info sul continente non disponibili 3
AF - Africa 1
Totale 11.344
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Nazione #
US - Stati Uniti d'America 9.419
CN - Cina 556
SG - Singapore 299
FI - Finlandia 231
DE - Germania 222
SE - Svezia 148
UA - Ucraina 117
VN - Vietnam 83
FR - Francia 81
GB - Regno Unito 57
IT - Italia 46
IN - India 15
IE - Irlanda 11
HK - Hong Kong 7
NL - Olanda 6
AU - Australia 5
CA - Canada 5
EU - Europa 3
JP - Giappone 3
PH - Filippine 3
TR - Turchia 3
AR - Argentina 2
ES - Italia 2
HU - Ungheria 2
KR - Corea 2
NZ - Nuova Zelanda 2
RO - Romania 2
AT - Austria 1
BD - Bangladesh 1
BR - Brasile 1
CL - Cile 1
DK - Danimarca 1
GL - Groenlandia 1
HR - Croazia 1
KZ - Kazakistan 1
MD - Moldavia 1
MY - Malesia 1
RU - Federazione Russa 1
ZA - Sudafrica 1
Totale 11.344
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Città #
Fairfield 1.445
Woodbridge 1.118
Chandler 873
Houston 684
Ann Arbor 608
Wilmington 601
Ashburn 588
Cambridge 541
Jacksonville 519
Seattle 506
Boardman 244
Princeton 237
Singapore 223
San Diego 165
Beijing 140
Des Moines 122
Nanjing 99
Dong Ket 83
Medford 82
Helsinki 79
Santa Clara 54
Roxbury 41
Changsha 32
Hebei 32
Nanchang 32
Shenyang 30
Jiaxing 26
Norwalk 25
Guangzhou 23
Tianjin 18
Falls Church 16
New York 15
Redwood City 15
Dallas 14
Kharkiv 14
Jinan 12
Dublin 11
London 11
Padova 10
Detroit 9
Ogden 9
Munich 8
Nürnberg 8
Renton 7
Dearborn 6
Indiana 6
Shanghai 6
Taizhou 6
Haikou 5
Kilburn 5
San Francisco 5
Tappahannock 5
Zhengzhou 5
Borås 4
Los Angeles 4
Rome 4
Buffalo 3
Chicago 3
Davao City 3
Hangzhou 3
Lanzhou 3
Tokyo 3
Toronto 3
Auburn Hills 2
Brisbane 2
Cittadella 2
Frankfurt am Main 2
Granollers 2
Hong Kong 2
Leawood 2
Milan 2
Münster 2
Ningbo 2
Pune 2
Rockville 2
Simi Valley 2
Southwark 2
Taiyuan 2
Venice 2
Washington 2
Wellington 2
Acton 1
Adelaide 1
Almaty 1
Ankara 1
Atlanta 1
Bucharest 1
Budapest 1
Buenos Aires 1
Camberley 1
Centurion 1
Chiswick 1
Clovis 1
Conwy 1
Copenhagen 1
Dongjak-gu 1
Edinburgh 1
Edmond 1
Fremont 1
Gilbert 1
Totale 9.566
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Nome #
ATP Site-Directed Inhibitors of Protein Kinase CK2: An Update 187
Inhibition of Protein Kinase CK2 by Flavonoids and Tyrphostins. A Structural Insight. 167
Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA) 161
Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2 156
Basic residues in the 74-83 and 191-198 segments of protein kinase CK2 catalytic subunit are implicated in negative but not in positive regulation by the beta-subunit 137
2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole: a novel powerful and selective inhibitor of protein kinase CK2 136
Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application. 133
Aurora-A site specificity: a study with synthetic peptide substrates 132
Inhibition of protein kinase CK2 by condensed polyphenolic derivatives. An in vitro and in vivo study 128
Plant Calreticulin is specifically and efficiently phosphorylated by protein kinase CK2. 127
Tetrabromocinnamic acid (TBCA) and related compounds represent a new class of specific protein kinase CK2 inhibitors 119
Possible implication of the golgi apparatus casein kinase in the phosphorylation of vesicle docking protein p115 ser-940: a study with peptide substrates 116
Synthetic peptides including acidic clusters as substrates of yeast casein kinase-2. 113
The role of calcium in oligogalacturonide-activated signalling in soybean cells 112
Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole 111
The pleiotropic protein kinase CK2 phosphorylates HTLV-1 Tax protein in vitro, targeting its PDZ-binding motif 110
Protein kinase CK2: a newcomer in the 'druggable kinome' 109
Development and exploitation of CK2 inhibitors 109
Unique features of HIV-1 Rev protein phosphorylation by protein kinase CK2 ('casein kinase-2') 108
The selectivity of inhibitors of protein kinase CK2: an update 106
The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks 106
Understanding protein kinase CK2 mis-regulation upon F508del CFTR expression 106
Cystic fibrosis transmembrane regulator fragments with the Phe508 deletion exert a dual allosteric control over the master kinase CK2 105
Structural features underlying the selectivity of the kinase inhibitors NBC and dNBC: role of a nitro group that discriminates between CK2 and DYRK1A 104
A study with model substrates of the structure of the sites phosphorylated by rat liver casein kinase TS. 102
Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization 100
Spectroscopic studies of the mitochondrial targeting signal of the HTLV-1 P13II protein: a-helix formation and aggregation in lipophilic environments 99
Toward the rational design of protein kinase casein kinase-2 inhibitors 99
Phosphorylation of casein fractions by rat liver 'phosvitin kinase'. 99
Phosphorylation of calmodulin fragments by protein kinase CK2. Mechanistic aspects and structural consequences 98
Eukaryotic translation-initiation factor eIF2β binds to protein kinase CK2: Effects on CK2α activity 97
Autophosphorylation at the regulatory beta subunit reflects the supramolecular organization of protein kinase CK2 96
Discrimination between the activity of protein kinase CK2 holoenzyme and its catalytic subunits 96
POLYAMINES AS NEGATIVE REGULATORS OF CASEIN KINASE-2 - THE PHOSPHORYLATION OF CALMODULIN TRIGGERED BY POLYLYSINE AND BY THE ALPHA[66-86] PEPTIDE IS PREVENTED BY SPERMINE 93
Phosphotyrosine specifies the phosphorylation by protein kinase CK2 of a peptide reproducing the activation loop of the insulin receptor protein tyrosine kinase. 93
A noncanonical sequence phosphorylated by casein kinase 1 in beta-catenin may play a role in casein kinase 1 targeting of important signaling proteins 93
Urolithin as a converging scaffold linking ellagic acid and coumarin analogues: design of potent protein kinase CK2 inhibitors. 93
Casein phosphatase dependent dephosphorylation of 32P-casein fractions labelled by two protein kinases. 91
Dual role of calsequestrin as substrate and inhibitor of casein kinase-1 and casein kinase-2 90
A Modified KESTREL Search Reveals a Basophilic Substrate Consensus for the Saccharomyces cerevisiae Npr1 Protein Kinase 88
Ca2+ binding protein calreticulin in Chlamydomonas reinhardtii (Chlorophyta): Biochemical characterization, differential expression during sexual reproduction and phylogenetic analysis. 86
Design and synthesis of two new peptide substrates for the specific and sensitive monitoring of casein kinases-1 and -2. 86
Golgi apparatus mammary gland casein kinase: monitoring by a specific peptide substrate and definition of specificity determinants 85
The use of soybean trypsin inhibitors as phosphorylatable substrates for a rat liver protein kinase. 85
Phosphorylation of alphaS2-casein by two rat liver 'casein kinases'. 83
Scouting Novel Protein Kinase A (PKA) Inhibitors by Using a Consensus Docking-Based Virtual Screening Approach 82
Substrate recognition by casein kinase-II: The role of histidine-160 82
pCMB treatment reveals the essential role of cysteinyl residues in conferring functional competence to the regulatory subunit of protein kinase CK2 82
Selectivity of 4,5,6,7-tetrabromo-benzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ("casein kinase-2") 82
Detection of type-2 casein kinase and its endogenous substrates in the components of the microsomal fraction of rat liver. 81
Inhibition of rat liver cytosol casein kinases by heparin. 81
Phosphorylation of HIV-1 Rev protein: implication of protein kinase CK2 and pro-directed kinases. 81
Different susceptibility of whole casein components to enzymatic phosphorylation by two forms of rat liver 'casein kinase'. 81
Cystic fibrosis transmembrane regulator fragments with the Phe508 deletion exert a dual allosteric control over the master kinase CK2. 80
The Dark Side of Protein Kinase CK2 Inhibition 79
The comparative efficiencies of the Ser(P)-, Thr(P)- and Tyr(P)-residues as specificity determinants for casein kinase-1. 79
Structural Features Underlying the Unusual Mode of Calmodulin Phosphorylation by Protein Kinase CK2: A Study with Synthetic Calmodulin Fragments 78
Phosphorylation of threonine and serine residues of native and partially dephosphorylated caseins by a rat liver cyclic AMP-insensitive protein kinase. 78
Tetraiodobenzimidazoles are potent inhibitors of protein kinase CK2 78
Xenopus laevis occludin. Identification of in vitro phosphorylation sites by protein kinase CK2 and association with cingulin 78
Synthetic peptides reproducing the site phosphorylated by cAMP-dependent protein kinase in protein phosphatase inhibitor-1. Effect of structural modifications on the phosphorylation efficiency. 77
Functional conservation of Calreticulin in Euglena gracilis. 77
Physical dissection of the structural elements responsible for regulatory properties and intersubunit interactions of protein kinase CK2 beta-subunit 75
A new procedure for the measurement of the protein-kinase-catalyzed incorporation of the gamma-32P-phosphoryl group of ATP into phospho-proteins and phosphopeptides. 75
Studies on the structural requirements of a microsomal cAMP-independent protein kinase. 75
Rapid and reliable identification of "casein kinases TS" in many tissues by means of a new specific and very suitable model substrate. 75
Cooperative modulation of protein kinase CK2 by separate domains of its regulatory beta-subunit 75
Unprecedented Selectivity and Structural Determinants of a New Class of Protein Kinase CK2 Inhibitors in Clinical Trials for the Treatment of Cancer 74
Ribofuranosyl-benzimidazole derivatives as inhibitors of casein kinase-2 and casein kinase-1. 73
Modulation of protein kinase CK2 activity by fragments of CFTR encompassing F508 may reflect functional links with cystic fibrosis pathogenesis 73
Different susceptibility of protein kinases to staurosporine inhibition. Kinetic studies and molecular bases for the resistance of protein kinase CK2 ('casein kinase-2) 73
Linear motifs in the C-terminus of D. melanogaster cryptochrome 72
Polycation-dependent, Ca2+-antagonized phosphorylation of calmodulin by casein kinase-2 and a spleen tyrosine protein kinase. 72
Site specificity of casein kinase-2 (TS) from rat liver cytosol. A study with model peptide substrates. 71
Coumarin as attractive casein kinase 2(CK2) inhibitor scaffold: an integrated approach to elucidate the putative binding motif and explain structure-activity relationship. 71
Regulatory subunit of protein kinase CK2 contributes to the recognition of the substrate consensus sequence. A study with an eIF2 beta-derived peptide 70
Structural features determining the site specificity of a rat liver cAMP-independent protein kinase. 70
Subunit structure and autophosphorylation mechanism of casein kinase-TS (type-2) from rat liver cytosol. 70
Casein kinases and their protein substrates in rat liver cytosol: evidence for their participation in multimolecular systems. 70
Phosphorylation of troponin T by casein kinase TS. 70
Identification of novel protein kinase CK1 delta (CK1 delta) inhibitors through structure-based virtual screening 69
Phosphorylation of src-phosphopeptides by casein kinases-1 and -2: favourable effect of phosphotyrosine. 69
Role of phosphorylated aminoacyl residues in generating atypical consensus sequences which are recognized by casein kinase-2 but not by casein kinase-1. 69
Rat liver casein kinases> substrate specificity and structural requirements 69
The effect of polylysine on casein-kinase-2 activity is influenced by both the structure of the protein/peptide substrates and the subunit composition of the enzyme. 69
Tyrosine versus serine/threonine phosphorylation by protein kinase casein kinase-2 - A study with peptide substrates derived from immunophilin Fpr3 68
Opposite and mutually incompatible structural requirements of type-2 casein kinase and cAMP-dependent protein kinase as visualized with synthetic peptide substrates. 68
Dissection of the dual function of the β-subunit of protein kinase CK2 (‘casein kinase-2’): a synthetic peptide reproducing the carboxyl-terminal domain mimicks the positive but not the negative effects of the whole protein 68
Phosphotyrosine as a specificity determinant for casein kinase-2, a growth related Ser/Thr-specific protein kinase. 68
Biochemical evidence that the N terminal segment of the alpha-subunit and the ß-subunit play interchangeable roles in the activation of protein kinase CK2 68
Role of the beta subunit of casein kinase-2 on the stability and specificity of the recombinant reconstituted holoenzyme. 67
Structure of the sites of substrate proteins undergoing phosphorylation by proteinkinases with special reference to liver "Casein Kinases" 67
Human protein kinase CK2: identification of structural elements of subunit ß participating in tight physical alfa-ß intersubunit contacts directly neighboured to a surface oriented region 66
The ATP,Mg-dependent protein phosphatase: regulation by casein kinase-1. 66
Calreticulin is expressed in Euglena gracilis 66
Location of the phosphorylation site for casein kinase-2 within the amino acid sequence of ornithine decarboxylase. 65
Dephosphorylation of synthetic phosphopeptides by protein phosphatase-T, a phosphothreonyl protein phosphatase. 63
Synthetic fragments of protamines as model substrates for rat liver cyclic AMP-dependent protein kinase. 63
Synthetic peptide substrates for casein kinase 2. Assessment of minimum structural requirements for phosphorylation. 63
Occludin dephosphorylation in early development of Xenopus laevis 62
Totale 8.943
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Categoria #
all - tutte 40.197
article - articoli 37.422
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 155
selected - selezionate 0
volume - volumi 722
Totale 78.496
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.647 0 0 0 0 238 199 202 261 246 262 151 88
2020/20211.372 60 97 41 117 111 130 37 130 214 111 172 152
2021/20221.957 19 238 306 167 57 98 92 253 67 14 265 381
2022/20231.672 297 186 13 237 300 263 4 117 178 8 55 14
2023/2024553 25 108 54 28 70 49 30 26 12 12 88 51
2024/2025744 4 196 128 120 296 0 0 0 0 0 0 0
Totale 11.364