MEGGIO, FLAVIO
 Distribuzione geografica
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Continente #
NA - Nord America 10.656
AS - Asia 3.761
EU - Europa 2.113
AF - Africa 923
SA - Sud America 677
OC - Oceania 112
Continente sconosciuto - Info sul continente non disponibili 41
Totale 18.283
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Nazione #
US - Stati Uniti d'America 10.151
SG - Singapore 1.411
CN - Cina 707
HK - Hong Kong 434
BR - Brasile 343
DE - Germania 275
FI - Finlandia 265
VN - Vietnam 242
SE - Svezia 183
UA - Ucraina 145
FR - Francia 106
RU - Federazione Russa 105
PL - Polonia 98
IT - Italia 85
GB - Regno Unito 74
AR - Argentina 65
IN - India 46
MX - Messico 46
IQ - Iraq 45
IE - Irlanda 44
NL - Olanda 44
ID - Indonesia 43
JP - Giappone 43
AO - Angola 41
AT - Austria 41
EC - Ecuador 38
TR - Turchia 37
TT - Trinidad e Tobago 37
VE - Venezuela 37
CV - Capo Verde 36
CZ - Repubblica Ceca 36
ES - Italia 35
LV - Lettonia 35
NC - Nuova Caledonia 35
PY - Paraguay 34
ZA - Sudafrica 34
CO - Colombia 33
PE - Perù 33
NP - Nepal 32
RO - Romania 32
SA - Arabia Saudita 32
GE - Georgia 31
JM - Giamaica 31
MA - Marocco 31
MN - Mongolia 31
TN - Tunisia 31
CI - Costa d'Avorio 30
GA - Gabon 30
KR - Corea 30
SO - Somalia 30
TJ - Tagikistan 30
AZ - Azerbaigian 29
CA - Canada 29
DK - Danimarca 29
GT - Guatemala 29
DZ - Algeria 28
EE - Estonia 28
IL - Israele 28
JO - Giordania 28
MR - Mauritania 28
MY - Malesia 28
BY - Bielorussia 27
ET - Etiopia 27
IS - Islanda 27
LA - Repubblica Popolare Democratica del Laos 27
LC - Santa Lucia 27
PS - Palestinian Territory 27
TZ - Tanzania 27
AE - Emirati Arabi Uniti 26
BB - Barbados 26
BZ - Belize 26
GF - Guiana Francese 26
KG - Kirghizistan 26
PK - Pakistan 26
PT - Portogallo 26
SK - Slovacchia (Repubblica Slovacca) 26
UZ - Uzbekistan 26
ZM - Zambia 26
AL - Albania 25
AM - Armenia 25
BF - Burkina Faso 25
HN - Honduras 25
HU - Ungheria 25
LU - Lussemburgo 25
ME - Montenegro 25
SI - Slovenia 25
YE - Yemen 25
BO - Bolivia 24
IR - Iran 24
NE - Niger 24
NI - Nicaragua 24
UG - Uganda 24
YT - Mayotte 24
BG - Bulgaria 23
CL - Cile 23
DJ - Gibuti 23
DO - Repubblica Dominicana 23
NO - Norvegia 23
PH - Filippine 23
ZW - Zimbabwe 23
Totale 17.206
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Città #
Fairfield 1.445
Woodbridge 1.119
Chandler 873
Ashburn 807
Singapore 746
Houston 685
Ann Arbor 608
Wilmington 602
Cambridge 541
Jacksonville 520
Seattle 509
Hong Kong 410
Boardman 244
Princeton 237
Beijing 190
San Diego 165
Santa Clara 133
Des Moines 123
Nanjing 99
Helsinki 93
Dong Ket 83
Medford 82
Bytom 65
Ho Chi Minh City 60
Los Angeles 45
Chicago 41
Roxbury 41
Hanoi 40
Luanda 35
Noumea 34
Changsha 33
Vienna 33
Dublin 32
Hebei 32
Nanchang 32
Praia 31
Shenyang 31
Ulan Bator 31
Dushanbe 30
Libreville 30
New York 29
Riga 29
Abidjan 28
Baku 28
Munich 28
Amman 27
Jiaxing 26
Lusaka 26
Addis Ababa 25
Bridgetown 25
Castries 25
Norwalk 25
Nouakchott 25
São Paulo 25
Guangzhou 24
Kampala 24
Tokyo 24
Managua 23
Niamey 23
Antananarivo 22
Kingston 22
Tashkent 22
Vientiane 22
Yerevan 22
Accra 21
Bishkek 21
Ouagadougou 21
Phnom Penh 21
Podgorica 21
Reykjavik 21
Tallinn 20
Tbilisi 20
Tianjin 20
Cayenne 19
Dallas 19
Dar es Salaam 19
Djibouti 19
Harare 19
Minsk 19
Lima 18
Montevideo 18
Panama City 18
Salt Lake City 18
Buffalo 17
Dakar 17
Kingstown 17
La Paz 17
Conakry 16
Falls Church 16
Havana 16
Kharkiv 16
Lilongwe 16
Ljubljana 16
Nairobi 16
Papeete 16
Pristina 16
Sanaa 16
Willemstad 16
Athens 15
Baghdad 15
Totale 12.235
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Nome #
ATP Site-Directed Inhibitors of Protein Kinase CK2: An Update 276
Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA) 235
Inhibition of Protein Kinase CK2 by Flavonoids and Tyrphostins. A Structural Insight. 230
Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2 228
Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application. 216
2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole: a novel powerful and selective inhibitor of protein kinase CK2 200
Tetrabromocinnamic acid (TBCA) and related compounds represent a new class of specific protein kinase CK2 inhibitors 194
Basic residues in the 74-83 and 191-198 segments of protein kinase CK2 catalytic subunit are implicated in negative but not in positive regulation by the beta-subunit 193
Aurora-A site specificity: a study with synthetic peptide substrates 190
Inhibition of protein kinase CK2 by condensed polyphenolic derivatives. An in vitro and in vivo study 178
Development and exploitation of CK2 inhibitors 178
Structural features underlying the selectivity of the kinase inhibitors NBC and dNBC: role of a nitro group that discriminates between CK2 and DYRK1A 176
A noncanonical sequence phosphorylated by casein kinase 1 in beta-catenin may play a role in casein kinase 1 targeting of important signaling proteins 170
Urolithin as a converging scaffold linking ellagic acid and coumarin analogues: design of potent protein kinase CK2 inhibitors. 170
Autophosphorylation at the regulatory beta subunit reflects the supramolecular organization of protein kinase CK2 168
Possible implication of the golgi apparatus casein kinase in the phosphorylation of vesicle docking protein p115 ser-940: a study with peptide substrates 167
Plant Calreticulin is specifically and efficiently phosphorylated by protein kinase CK2. 165
The selectivity of inhibitors of protein kinase CK2: an update 165
The pleiotropic protein kinase CK2 phosphorylates HTLV-1 Tax protein in vitro, targeting its PDZ-binding motif 165
The role of calcium in oligogalacturonide-activated signalling in soybean cells 163
Cystic fibrosis transmembrane regulator fragments with the Phe508 deletion exert a dual allosteric control over the master kinase CK2 162
Understanding protein kinase CK2 mis-regulation upon F508del CFTR expression 161
Synthetic peptides including acidic clusters as substrates of yeast casein kinase-2. 161
The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks 157
A Modified KESTREL Search Reveals a Basophilic Substrate Consensus for the Saccharomyces cerevisiae Npr1 Protein Kinase 154
Scouting Novel Protein Kinase A (PKA) Inhibitors by Using a Consensus Docking-Based Virtual Screening Approach 153
Unique features of HIV-1 Rev protein phosphorylation by protein kinase CK2 ('casein kinase-2') 151
A study with model substrates of the structure of the sites phosphorylated by rat liver casein kinase TS. 150
Casein phosphatase dependent dephosphorylation of 32P-casein fractions labelled by two protein kinases. 150
Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole 149
Spectroscopic studies of the mitochondrial targeting signal of the HTLV-1 P13II protein: a-helix formation and aggregation in lipophilic environments 148
Toward the rational design of protein kinase casein kinase-2 inhibitors 148
Phosphorylation of calmodulin fragments by protein kinase CK2. Mechanistic aspects and structural consequences 148
Protein kinase CK2: a newcomer in the 'druggable kinome' 147
Unprecedented Selectivity and Structural Determinants of a New Class of Protein Kinase CK2 Inhibitors in Clinical Trials for the Treatment of Cancer 147
Dual role of calsequestrin as substrate and inhibitor of casein kinase-1 and casein kinase-2 146
Discrimination between the activity of protein kinase CK2 holoenzyme and its catalytic subunits 146
Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization 144
Xenopus laevis occludin. Identification of in vitro phosphorylation sites by protein kinase CK2 and association with cingulin 144
Eukaryotic translation-initiation factor eIF2β binds to protein kinase CK2: Effects on CK2α activity 142
Phosphorylation of casein fractions by rat liver 'phosvitin kinase'. 139
Tetraiodobenzimidazoles are potent inhibitors of protein kinase CK2 139
Phosphotyrosine specifies the phosphorylation by protein kinase CK2 of a peptide reproducing the activation loop of the insulin receptor protein tyrosine kinase. 138
Cystic fibrosis transmembrane regulator fragments with the Phe508 deletion exert a dual allosteric control over the master kinase CK2. 138
Ca2+ binding protein calreticulin in Chlamydomonas reinhardtii (Chlorophyta): Biochemical characterization, differential expression during sexual reproduction and phylogenetic analysis. 137
Modulation of protein kinase CK2 activity by fragments of CFTR encompassing F508 may reflect functional links with cystic fibrosis pathogenesis 134
Selectivity of 4,5,6,7-tetrabromo-benzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ("casein kinase-2") 134
Coumarin as attractive casein kinase 2(CK2) inhibitor scaffold: an integrated approach to elucidate the putative binding motif and explain structure-activity relationship. 134
POLYAMINES AS NEGATIVE REGULATORS OF CASEIN KINASE-2 - THE PHOSPHORYLATION OF CALMODULIN TRIGGERED BY POLYLYSINE AND BY THE ALPHA[66-86] PEPTIDE IS PREVENTED BY SPERMINE 133
Golgi apparatus mammary gland casein kinase: monitoring by a specific peptide substrate and definition of specificity determinants 133
Regulatory subunit of protein kinase CK2 contributes to the recognition of the substrate consensus sequence. A study with an eIF2 beta-derived peptide 132
Cooperative modulation of protein kinase CK2 by separate domains of its regulatory beta-subunit 132
Linear motifs in the C-terminus of D. melanogaster cryptochrome 130
Occludin dephosphorylation in early development of Xenopus laevis 129
The Dark Side of Protein Kinase CK2 Inhibition 129
Design and synthesis of two new peptide substrates for the specific and sensitive monitoring of casein kinases-1 and -2. 128
The use of soybean trypsin inhibitors as phosphorylatable substrates for a rat liver protein kinase. 127
Tyrosine versus serine/threonine phosphorylation by protein kinase casein kinase-2 - A study with peptide substrates derived from immunophilin Fpr3 126
Phosphorylation of alphaS2-casein by two rat liver 'casein kinases'. 123
pCMB treatment reveals the essential role of cysteinyl residues in conferring functional competence to the regulatory subunit of protein kinase CK2 123
Different susceptibility of protein kinases to staurosporine inhibition. Kinetic studies and molecular bases for the resistance of protein kinase CK2 ('casein kinase-2) 123
Identification of novel protein kinase CK1 delta (CK1 delta) inhibitors through structure-based virtual screening 122
Detection of type-2 casein kinase and its endogenous substrates in the components of the microsomal fraction of rat liver. 121
A new procedure for the measurement of the protein-kinase-catalyzed incorporation of the gamma-32P-phosphoryl group of ATP into phospho-proteins and phosphopeptides. 120
Functional conservation of Calreticulin in Euglena gracilis. 120
Phosphorylation of HIV-1 Rev protein: implication of protein kinase CK2 and pro-directed kinases. 119
Substrate recognition by casein kinase-II: The role of histidine-160 118
Different susceptibility of whole casein components to enzymatic phosphorylation by two forms of rat liver 'casein kinase'. 118
Calreticulin is expressed in Euglena gracilis 117
Biochemical properties of native forms of DMPK. 116
Phosphorylation of threonine and serine residues of native and partially dephosphorylated caseins by a rat liver cyclic AMP-insensitive protein kinase. 116
Casein kinases and their protein substrates in rat liver cytosol: evidence for their participation in multimolecular systems. 116
Physical dissection of the structural elements responsible for regulatory properties and intersubunit interactions of protein kinase CK2 beta-subunit 115
Phosphorylation and activation of protein kinase CK2 by p34cdc2 are independent events. 114
Biochemical evidence that the N terminal segment of the alpha-subunit and the ß-subunit play interchangeable roles in the activation of protein kinase CK2 114
Inhibition of rat liver cytosol casein kinases by heparin. 113
Synthetic peptides reproducing the site phosphorylated by cAMP-dependent protein kinase in protein phosphatase inhibitor-1. Effect of structural modifications on the phosphorylation efficiency. 113
Site specificity of casein kinase-2 (TS) from rat liver cytosol. A study with model peptide substrates. 113
Cross talk between protein kinase CK2 and eukaryotic translation initiation factor eIF2beta subunit. 113
Ribofuranosyl-benzimidazole derivatives as inhibitors of casein kinase-2 and casein kinase-1. 112
The comparative efficiencies of the Ser(P)-, Thr(P)- and Tyr(P)-residues as specificity determinants for casein kinase-1. 112
Structural Features Underlying the Unusual Mode of Calmodulin Phosphorylation by Protein Kinase CK2: A Study with Synthetic Calmodulin Fragments 111
Rat liver casein kinases> substrate specificity and structural requirements 111
Polycation-dependent, Ca2+-antagonized phosphorylation of calmodulin by casein kinase-2 and a spleen tyrosine protein kinase. 111
Dephosphorylation of synthetic phosphopeptides by protein phosphatase-T, a phosphothreonyl protein phosphatase. 110
Phosphorylation activity of endogenous myotonic dystrophy protein kinase. 109
Inhibition of oligosaccharide-elicited Ca2+ transients by 4,5,6,7-tetrabromobenzotriazole in Arabidopsis cell cultures 109
Rapid and reliable identification of "casein kinases TS" in many tissues by means of a new specific and very suitable model substrate. 109
HIV-1 Rev transactivator: a beta-subunit directed substrate and effector of protein kinase CK2 108
Subunit structure and autophosphorylation mechanism of casein kinase-TS (type-2) from rat liver cytosol. 108
Phosphorylation of troponin T by casein kinase TS. 108
Role of phosphorylated aminoacyl residues in generating atypical consensus sequences which are recognized by casein kinase-2 but not by casein kinase-1. 108
Phosphotyrosine as a specificity determinant for casein kinase-2, a growth related Ser/Thr-specific protein kinase. 107
The effect of polylysine on casein-kinase-2 activity is influenced by both the structure of the protein/peptide substrates and the subunit composition of the enzyme. 106
Structural features determining the site specificity of a rat liver cAMP-independent protein kinase. 105
Studies on the structural requirements of a microsomal cAMP-independent protein kinase. 105
Phosphorylation of src-phosphopeptides by casein kinases-1 and -2: favourable effect of phosphotyrosine. 104
Functional analysis of CK2beta-derived synthetic fragments 103
Structure of the sites of substrate proteins undergoing phosphorylation by proteinkinases with special reference to liver "Casein Kinases" 103
The carboxy-terminal domain of Grp94 binds to protein kinase CK2 alpha but not to CK2 holoenzyme 102
Totale 13.955
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Categoria #
all - tutte 57.316
article - articoli 52.836
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 254
selected - selezionate 0
volume - volumi 1.107
Totale 111.513
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021946 0 0 0 0 0 130 37 130 214 111 172 152
2021/20221.957 19 238 306 167 57 98 92 253 67 14 265 381
2022/20231.672 297 186 13 237 300 263 4 117 178 8 55 14
2023/2024553 25 108 54 28 70 49 30 26 12 12 88 51
2024/20252.438 4 196 128 120 393 64 81 186 186 75 441 564
2025/20265.246 267 891 1.495 1.685 867 41 0 0 0 0 0 0
Totale 18.304