MERCORELLI, BEATRICE
MERCORELLI, BEATRICE
Dipartimento di Medicina Molecolare - DMM
4,6-Diphenylpyridines as Promising Novel Anti-Influenza Agents Targeting the PA-PB1 Protein-Protein Interaction: Structure-Activity Relationships Exploration with the Aid of Molecular Modeling
2016 Trist, Iuni M. L.; Nannetti, Giulio; Tintori, Cristina; Fallacara, Anna Lucia; Deodato, Davide; Mercorelli, Beatrice; Palu', Giorgio; Wijtmans, Maikel; Gospodova, Tzveta; Edink, Ewald; Verheij, Mark; De Esch, Iwan; Viteva, Lilia; Loregian, Arianna; Botta, Maurizio
A 6-Aminoquinolone Compound, WC5, with Potent and Selective Anti-Human Cytomegalovirus Activity
2009 Mercorelli, Beatrice; Muratore, Giulia; Sinigalia, Elisa; Tabarrini, O; Biasolo, MARIA-ANGELA; Cecchetti, V; Palu', Giorgio; Loregian, Arianna
A Broad anti-influenza hybrid small molecule that potently disrupts the interaction of polymerase acidic protein-basic protein 1 (PA-PB1) subunits
2015 Massari, Serena; Nannetti, Giulio; Desantis, Jenny; Muratore, Giulia; Sabatini, Stefano; Manfroni, Giuseppe; Mercorelli, Beatrice; Cecchetti, Violetta; Palu', Giorgio; Cruciani, Gabriele; Loregian, Arianna; Goracci, Laura; Tabarrini, Oriana
A novel small-molecule inhibitor of the human papillomavirus E6-p53 interaction that reactivates p53 function and blocks cancer cells growth
2020 Celegato, M.; Messa, L.; Goracci, L.; Mercorelli, B.; Bertagnin, C.; Spyrakis, F.; Suarez, I.; Cousido-Siah, A.; Trave, G.; Banks, L.; Cruciani, G.; Palu, G.; Loregian, A.
A point mutation in a herpesvirus polymerase determines neuropathogenicity.
2007 Goodman, L. B.; Loregian, Arianna; Perkins, G. A.; Nugent, J; Buckles, E. L.; Mercorelli, Beatrice; Kydd, J. H.; Palu', Giorgio; Smith, K. C.; Osterrieder, N; DAVIS POYNTER, N.
A quantitative LumiFluo assay to test inhibitory compounds blocking p53 degradation induced by human papillomavirus oncoprotein E6 in living cells
2018 Messa, Lorenzo; Celegato, Marta; Bertagnin, Chiara; Mercorelli, Beatrice; Nannetti, Giulio; Palù, Giorgio; Loregian, Arianna
A small molecule targeting the interaction between human papillomavirus E7 oncoprotein and cellular phosphatase PTPN14 exerts antitumoral activity in cervical cancer cells
2023 Bertagnin, C.; Messa, L.; Pavan, M.; Celegato, M.; Sturlese, M.; Mercorelli, B.; Moro, S.; Loregian, A.
Antiviral strategies against influenza virus: towards new therapeutic approaches.
2014 Loregian, Arianna; Mercorelli, Beatrice; Nannetti, Giulio; Compagnin, Chiara; Palu', Giorgio
Approaches for the generation of new anti-cytomegalovirus agents: identification of protein-protein interaction inhibitors and compounds against the HCMV IE2 protein.
2014 Mercorelli, Beatrice; Gribaudo, G; Palu', Giorgio; Loregian, Arianna
Binding parameters and thermodynamics of the interaction of the human cytomegalovirus DNA polymerase accessory protein, UL44, with DNA: implications for the processivity mechanism
2007 Loregian, Arianna; Sinigalia, Elisa; Mercorelli, Beatrice; Palu', Giorgio; Coen, Dm
Caratterizzazione di nuovi composti antivirali contro il citomegalovirus umano e studio del meccanismo di neuropatogenocità nel herpesvirus equino di tipo 1
2009 Mercorelli, Beatrice
Composition and methods for the treatment of pathological condition associated with cytomegalovirus infection.
2010 Loregian, Arianna; Palu', Giorgio; Mercorelli, Beatrice; Tabarrini, O.; Cecchetti, V.
Design, synthesis, and biological evaluation of first-in-class indomethacin-based PROTACs degrading SARS-CoV-2 main protease and with broad-spectrum antiviral activity
2024 Desantis, Jenny; Bazzacco, Alessandro; Eleuteri, Michela; Tuci, Sara; Bianconi, Elisa; Macchiarulo, Antonio; Mercorelli, Beatrice; Loregian, Arianna; Goracci, Laura
Design, Synthesis, and Biological Evaluation of Trisubstituted Piperazine Derivatives as Noncovalent Severe Acute Respiratory Syndrome Coronavirus 2 Main Protease Inhibitors with Improved Antiviral Activity and Favorable Druggability
2023 Gao, S.; Song, L.; Sylvester, K.; Mercorelli, B.; Loregian, A.; Toth, K.; Weisse, R. H.; Useini, A.; Strater, N.; Yang, M.; Ye, B.; Tollefson, A. E.; Muller, C. E.; Liu, X.; Zhan, P.
Design, synthesis, and evaluation of WC5 analogues as inhibitors of human cytomegalovirus Immediate-Early 2 protein, a promising target for anti-HCMV treatment.
2013 Massari, S; Mercorelli, Beatrice; Sancineto, L; Sabatini, S; Cecchetti, V; Gribaudo, G; Palu', Giorgio; Pannecouque, C; Loregian, Arianna; Tabarrini, O.
Discovery of novel SARS-CoV-2 inhibitors targeting the main protease Mpro by virtual screenings and hit optimization
2022 Mercorelli, Beatrice; Desantis, Jenny; Celegato, Marta; Bazzacco, Alessandro; Siragusa, Lydia; Benedetti, Paolo; Eleuteri, Michela; Croci, Federico; Cruciani, Gabriele; Goracci, Laura; Loregian, Arianna
Divide et impera: An In Silico Screening Targeting HCMV ppUL44 Processivity Factor Homodimerization Identifies Small Molecules Inhibiting Viral Replication
2021 Ghassabian, Hanieh; Falchi, F; Timmoneri, M; Mercorelli, B; Loregian, A; Palu, G; Alvisi, G
Drug Repurposing Approach Identifies Inhibitors of the Prototypic Viral Transcription Factor IE2 that Block Human Cytomegalovirus Replication
2016 Mercorelli, Beatrice; Luganini, Anna; Nannetti, Giulio; Tabarrini, Oriana; Palu', Giorgio; Gribaudo, Giorgio; Loregian, Arianna
Drug Repurposing Campaigns for Human Cytomegalovirus Identify a Natural Compound Targeting the Immediate-Early 2 (IE2) Protein: A Comment on "The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts"
2019 Mercorelli, Beatrice; Luganini, Anna; Palù, Giorgio; Gribaudo, Giorgio; Loregian, Arianna
Drug Repurposing for Viral Infectious Diseases: How Far Are We?
2018 Mercorelli, Beatrice; Palù, Giorgio; Loregian, Arianna