QUINTIERI, LUIGI
 Distribuzione geografica
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Continente #
NA - Nord America 5.649
AS - Asia 1.882
EU - Europa 1.360
SA - Sud America 515
AF - Africa 447
OC - Oceania 63
Continente sconosciuto - Info sul continente non disponibili 25
Totale 9.941
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Nazione #
US - Stati Uniti d'America 5.420
SG - Singapore 553
CN - Cina 463
BR - Brasile 320
IT - Italia 279
HK - Hong Kong 231
DE - Germania 154
FI - Finlandia 112
VN - Vietnam 109
SE - Svezia 76
FR - Francia 72
IN - India 72
GB - Regno Unito 67
UA - Ucraina 61
RU - Federazione Russa 60
PL - Polonia 55
NL - Olanda 54
AR - Argentina 53
KR - Corea 27
ZA - Sudafrica 26
CL - Cile 23
EC - Ecuador 23
AE - Emirati Arabi Uniti 22
AT - Austria 22
AU - Australia 22
CH - Svizzera 21
CO - Colombia 21
DZ - Algeria 21
TR - Turchia 21
CA - Canada 20
MY - Malesia 20
TJ - Tagikistan 20
BO - Bolivia 19
IE - Irlanda 19
IR - Iran 18
ME - Montenegro 18
MR - Mauritania 18
BZ - Belize 17
JP - Giappone 17
VE - Venezuela 17
AZ - Azerbaigian 16
CI - Costa d'Avorio 16
IL - Israele 16
KG - Kirghizistan 16
PS - Palestinian Territory 16
AL - Albania 15
DK - Danimarca 15
HR - Croazia 15
MX - Messico 15
NP - Nepal 15
ES - Italia 14
ET - Etiopia 14
ID - Indonesia 14
JM - Giamaica 14
KZ - Kazakistan 14
LV - Lettonia 14
NI - Nicaragua 14
PA - Panama 14
PK - Pakistan 14
RS - Serbia 14
TN - Tunisia 14
TZ - Tanzania 14
YT - Mayotte 14
BE - Belgio 13
GR - Grecia 13
IQ - Iraq 13
JO - Giordania 13
KE - Kenya 13
MG - Madagascar 13
ML - Mali 13
PE - Perù 13
PR - Porto Rico 13
SK - Slovacchia (Repubblica Slovacca) 13
TW - Taiwan 13
UZ - Uzbekistan 13
BD - Bangladesh 12
BJ - Benin 12
CZ - Repubblica Ceca 12
EE - Estonia 12
GT - Guatemala 12
IS - Islanda 12
LB - Libano 12
LC - Santa Lucia 12
LU - Lussemburgo 12
LY - Libia 12
MA - Marocco 12
MK - Macedonia 12
NC - Nuova Caledonia 12
NO - Norvegia 12
PG - Papua Nuova Guinea 12
PH - Filippine 12
RO - Romania 12
AD - Andorra 11
BB - Barbados 11
BF - Burkina Faso 11
BG - Bulgaria 11
BY - Bielorussia 11
CY - Cipro 11
DJ - Gibuti 11
GA - Gabon 11
Totale 9.448
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Città #
Fairfield 636
Ashburn 512
Ann Arbor 471
Chandler 432
Woodbridge 427
Singapore 371
Houston 328
Cambridge 297
Jacksonville 258
Seattle 254
Wilmington 243
Hong Kong 217
Santa Clara 170
Beijing 131
Boardman 117
Padova 106
Princeton 97
San Diego 54
Medford 52
Des Moines 49
Munich 47
Nanjing 47
Bytom 45
Helsinki 40
Los Angeles 40
Ho Chi Minh City 30
Pune 25
Buffalo 24
São Paulo 24
Hefei 20
Dong Ket 19
Dushanbe 19
Buenos Aires 18
London 18
Shenyang 18
Hanoi 17
Hyderabad 17
Shanghai 17
Bishkek 16
Dublin 16
Nouakchott 16
Podgorica 16
Stockholm 16
Abidjan 15
Baku 15
Milan 15
Nanchang 15
New York 15
Vienna 15
Brooklyn 14
Panama City 14
Redwood City 14
Amman 13
Chicago 13
Guangzhou 13
Jinan 13
Managua 13
Rome 13
Sydney 13
Antananarivo 12
Bamako 12
Changsha 12
Cotonou 12
Mamoudzou 12
Nairobi 12
Port Moresby 12
Riga 12
Andorra la Vella 11
Bridgetown 11
Conakry 11
Dakar 11
Dar es Salaam 11
Jiaxing 11
Libreville 11
Norwalk 11
Noumea 11
Paris 11
Tashkent 11
Tianjin 11
Belo Horizonte 10
Castries 10
Falls Church 10
Havana 10
Johannesburg 10
Kigali 10
Kingston 10
Lima 10
Lusaka 10
Atlanta 9
Belize City 9
Boston 9
Dili 9
Hebei 9
La Paz 9
Luanda 9
Nassau 9
Papeete 9
Tallinn 9
Tirana 9
Djibouti 8
Totale 6.435
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Nome #
Cellular pharmacology of PNU-159682, a liver microsomal metabolite of methoxymorpholinyl doxorubicin (Nemorubicin; MMDX) 249
Ethylene negatively regulates transcript abundance of ROP-GAP rheostat-encoding genes and affects apoplastic reactive oxygen species homeostasis in epicarps of cold stored apple fruits 239
Synthesis and characterisation of a new benzamide-containing nitrobenzoxadiazole as a GSTP1-1 inhibitor endowed with high stability to metabolic hydrolysis 230
A paclitaxel-hyaluronan bioconjugate targeting ovarian cancer affords a potent in vivo therapeutic activity. 219
Evaluating the effects of fluorine on biological properties and metabolic stability of some antitubulin 3-substituted 7-phenyl-pyrroloquinolinones 216
Synthesis, structure-activity relationships and biological evaluation of 7-phenyl-pyrroloquinolinone 3-amide derivatives as potent antimitotic agents 203
The nitrobenzoxadiazole derivative MC3181 blocks melanoma invasion and metastasis 194
In vitro hepatic conversion of the anticancer agent nemorubicin to its active metabolite PNU-159682 in mice, rats and dogs: A comparison with human liver microsomes 190
Formation and antitumor activity of PNU-159682, a major metabolite of nemorubicin in human liver microsomes 187
Flavonoids diosmetin and luteolin inhibit midazolam metabolism by human liver microsomes and recombinant CYP 3A4 and CYP3A5 enzymes 175
Hyperthermic isolated perfusion with low-dose tumor necrosis factor alpha and doxorubicin for the treatment of limb-threatening soft tissue sarcomas. 170
Virtual Cross-Linking of the Active Nemorubicin Metabolite PNU-159682 to Double-Stranded DNA 168
R-warfarin anticoagulant effect 166
Flavonoids diosmetin and hesperetin are potent inhibitors of cytochrome P450 2C9-mediated drug metabolism in vitro. 162
LKB1 loss is associated with glutathione deficiency under oxidative stress and sensitivity of cancer cells to cytotoxic drugs and γ-irradiation 161
Thiol-Activated Anticancer Agents: The State of the Art 160
A novel orally active water-soluble inhibitor of human glutathione transferase exerts a potent and selective antitumor activity against human melanoma xenografts 155
Sex-related differences in renal toxicodynamics in rodents 153
Midazolam oxidation in cattle liver microsomes: The role of cytochrome P450 3A 152
In vitro evidence that carteolol is a nonconventional partial agonist of guinea pig cardiac beta1-adrenoceptors: a comparison with xamoterol. 151
Overcoming Cancer Cell Drug Resistance by a Folic Acid Targeted Polymeric Conjugate of Buthionine Sulfoximine 151
Glutathione transferases as targets for cancer therapy. 145
Gender and species differences in hepatic conversion of Nemorubicin to its highly cytotoxic metabolite, PNU-159682 139
Delivery of methoxymorpholinyl doxorubicin by interleukin 2-activated NK cells: effect in mice bearing hepatic metastases 137
Relative contribution of cytochrome P450 3A to midazolam oxidation in cattle liver microsomes. 136
Inhibition of cytochrome P450 2C8-mediated drug metabolism by the flavonoid diosmetin. 135
Prolonging the stability of cetuximab (Erbitux®) and panitumumab (Vectibix®): An orthogonal assessment of physicochemical, biological and microbiological properties of original opened glass vials and diluted saline preparations 134
Pentoxifylline and its major oxidative metabolites exhibit different pharmacological properties 134
Identification of Molecular Determinants of Tumor Sensitivity and Resistance to Anticancer Drugs 133
A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability 133
Synthesis and preliminary in vitro biological evaluation of 4-[(4-hydroxyphenyl)sulfanyl]but-3-en-2-one, a 4-mercaptophenol derivative designed as a novel bifunctional antimelanoma agent. 130
In vitro and in vivo antitumor activity of nemorubicin metabolites 127
CD45 regulates apoptosis induced by extracellular adenosine triphosphate and cytotoxic T lymphocytes 127
Pharmacokinetics of intraperitoneal cisplatin and doxorubicin 126
Olopatadine: a drug for allergic conjunctivitis targeting the mast cell 123
Characterization of water-soluble esters of nitrobenzoxadiazole-based GSTP1-1 inhibitors for cancer treatment 122
Vanillin analogues o-vanillin and 2,4,6-trihydroxybenzaldehyde inhibit NFκB activation and suppress growth of A375 human melanoma 121
Irreversible CYP3A Inhibition Accompained by Plasma Protein-Binding Displacement: A Comparative Analysis in Subjects with normal and impaired liver function. 120
Screening of sulfasalazine analogues for inhibition of human glutathione transferase P1-1, a target for anticancer therapy 120
Nemorubicin: a third-generation anthracycline active on hepatocellularr carcinoma (HCC) 119
Cancer gene therapy by DNA immunization 119
Design and synthesis of a tripartate paclitaxel prodrug for melanoma therapy 118
4-[(4'-idrossifenil)sulfanil]-3-buten-2-one (HPSBO), un potenziale "lead" per losviluppo di agenti bifunzionali per la terapia mirata del melanoma 117
Polysialic acid as a drug carrier: evaluation of a new polysialic acid–epirubicin conjugate and its comparison against established drug carriers 117
Fluorescent, internally quenced, peptides for exploring the pH-dependent substrate specificity of cathepsin B 117
Therapeutic effect of interleukin 12 on mouse haemangiosarcomas is not associated with an increased anti-tumour cytotoxic T-lymphocyte activity 113
Oral administration of trans-resveratrol to guinea pigs increases cardiac DT-diaphorase and catalase activities, and protects isolated atria from menadione toxicity 113
Initial in vitro interspecies comparison of hepatic metabolism of the investigational anticancer agent 6-(7-nitro-2,1,3-benzoxadiazol-4- ylthio)hexanol (NBDHEX) 112
Comparison of the binding affinity of CGP-12177A at recombinant rat alpha(1D)-adrenoceptors expressed in BHK-21 cell membranes and alpha(1)-adrenoceptors present in rat cerebral cortex membranes 109
Cytochrome P450 3A4 mediates transformation of methoxymorpholinyl doxorubicin (Nemorubicin; MMDX) to highly potent metabolite PNU-159682 in human liver microsomes 108
Hyperthermic isolated perfusion with low-dose TNFalpha and doxorubicin in patients with locally advanced soft tissue limb sarcomas. 108
Binding and reactivity towards DNA of PNU-159682, the highly cytotoxic metabolite of nemorubicin 107
Carteolol, a non-conventional partial agonist of beta(1)-adrenoceptors, relaxes phenylephrine-constricted rat aorta through antagonism at alpha(1)-adrenoceptors 102
Cell-secreted vesicles: Novel opportunities in cancer diagnosis, monitoring and treatment 102
Determinants of Drug Resistance in B-Cell Non-Hodgkin Lymphomas: The Case of Lymphoplasmacytic Lymphoma/Waldenström Macroglobulinemia 102
Antitumors DNA vaccines [Vaccini antitumorali a DNA] 101
Initial characterization of the metabolic stability of the selective and potent glutathione transferase P1-1 inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) in liver microsomes and cytosol: an interspecies comparison 97
Design and synthesis of a tripartate paclitaxel prodrug for melanoma therapy. 96
Anti-Cancer Agents in Medicinal Chemistry: Editorial 96
Characterization of the interaction with nucleic acids of the highly cytotoxic oxidative metabolite of the anthracycline nemorubicin by fluorescence quenching assays 95
Evaluation of inhibitory activity and selectivity of novel sulfasalazine analogues towards human glutathione transferases 95
A genetic algorithm-based approach for the prediction of metabolic drug-drug interactions involving CYP2C8 or CYP2B6 90
Methoxymorpholinyl doxorubicin (PNU152243) antitumor activity in vivo: Involvement of cytochrome P450 (CYP)-mediated drug metabolism 90
In vitro inhibition of cytochrome P450 (CYP) 2C8-mediated drug metabolism by the flavonoid diosmetin 89
Metabolic effects of antiangiogenic drugs in tumors: Therapeutic implications 89
Sensitivity of different cell lines to nemorubicin and its metabolites 87
Development of a rapid reverse-phase HPLC method for the phenotypic analysis of gemcitabine deamination 86
Metabolismo del diclofenac in una linea cellulare stabilizzata di Catharanthus roseus 86
A Quantitative Approach to the Prediction of Drug-Drug Interactions Mediated by Cytochrome P450 2C8 Inhibition 85
Enzymes as useful tools and potential targets in cancer chemotherapy. Editorial 84
Insights into the cellular pharmacokinetics and pharmacodynamics of thiopurine antimetabolites in a model of human intestinal cells 81
Quantitative Prediction of Drug Interactions Caused by Cytochrome P450 2B6 Inhibition or Induction 80
Nemorubicin synergizes with agents currently used for the treatment of hepatocellular carcinoma (HCC) 80
The Nitrobenzoxadiazole Derivative NBDHEX Behaves as Plasmodium falciparum Gametocyte Selective Inhibitor with Malaria Parasite Transmission Blocking Activity 80
Preclinical activity against metastases of Nemorubicin, a DNA-intercalating cytotoxic agent for the treatment of hepatocellular carcinoma 73
Nucleotide excision repair (NER) plays a central role in the mechanism of action of nemorubicin: Silencing of XPG as a mechanism of resistance 70
In vivo antitumor activity and host toxicity of methoxymorpholinyl doxorubicin: Role of cytochrome P450 3A 69
Allergic Conjunctivitis Management: Update on Ophthalmic Solutions 68
Nemorubicin: A doxorubicin-like structure with a novel mechanism of action different from anthracyclines. 51
A genetic algorithm-based approach for quantitative prediction of drug-drug interactions caused by cytochrome P450 3A inhibitors and inducers in dogs and cats 48
Totale 10.042
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Categoria #
all - tutte 32.318
article - articoli 26.403
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 469
Totale 59.190
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021778 0 0 0 61 55 96 15 68 136 162 98 87
2021/2022910 7 103 135 62 36 67 19 127 39 19 86 210
2022/2023835 119 85 19 101 150 127 1 68 116 10 22 17
2023/2024485 39 72 47 27 28 78 52 21 14 17 44 46
2024/20252.003 29 161 118 90 289 94 68 208 125 77 277 467
2025/20262.399 425 635 972 367 0 0 0 0 0 0 0 0
Totale 10.042