QUINTIERI, LUIGI
 Distribuzione geografica
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Continente #
NA - Nord America 8.371
AS - Asia 4.538
EU - Europa 2.028
SA - Sud America 745
AF - Africa 662
Continente sconosciuto - Info sul continente non disponibili 136
OC - Oceania 80
Totale 16.560
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Nazione #
US - Stati Uniti d'America 7.938
SG - Singapore 1.327
CN - Cina 895
VN - Vietnam 680
IT - Italia 509
BR - Brasile 427
HK - Hong Kong 357
BD - Bangladesh 287
FR - Francia 173
DE - Germania 171
IN - India 149
FI - Finlandia 129
GB - Regno Unito 127
SE - Svezia 92
AR - Argentina 89
CA - Canada 89
NL - Olanda 82
PL - Polonia 82
UA - Ucraina 73
RU - Federazione Russa 67
ZA - Sudafrica 55
JP - Giappone 52
ID - Indonesia 49
PH - Filippine 48
TR - Turchia 48
IQ - Iraq 47
EC - Ecuador 40
CO - Colombia 38
MX - Messico 38
SA - Arabia Saudita 38
KR - Corea 37
PK - Pakistan 36
AE - Emirati Arabi Uniti 32
AT - Austria 32
ES - Italia 32
CH - Svizzera 31
CL - Cile 31
MY - Malesia 29
UZ - Uzbekistan 29
AU - Australia 28
JM - Giamaica 28
AZ - Azerbaigian 27
DZ - Algeria 27
IR - Iran 27
VE - Venezuela 27
BJ - Benin 26
BO - Bolivia 26
ET - Etiopia 26
TN - Tunisia 26
JO - Giordania 24
NI - Nicaragua 24
PS - Palestinian Territory 24
BZ - Belize 23
CR - Costa Rica 23
GR - Grecia 23
IE - Irlanda 23
IL - Israele 23
CI - Costa d'Avorio 22
DK - Danimarca 22
KE - Kenya 22
KZ - Kazakistan 22
MA - Marocco 22
NP - Nepal 21
HR - Croazia 20
KG - Kirghizistan 20
PE - Perù 20
RS - Serbia 20
TJ - Tagikistan 20
TW - Taiwan 20
AL - Albania 19
HN - Honduras 19
LB - Libano 19
ME - Montenegro 19
MR - Mauritania 19
PA - Panama 19
PY - Paraguay 19
BG - Bulgaria 18
GN - Guinea 18
PT - Portogallo 18
TZ - Tanzania 18
BW - Botswana 17
CZ - Repubblica Ceca 17
GT - Guatemala 17
HU - Ungheria 17
LC - Santa Lucia 17
PR - Porto Rico 17
BE - Belgio 16
CY - Cipro 16
GF - Guiana Francese 16
IS - Islanda 16
LU - Lussemburgo 16
LV - Lettonia 16
LY - Libia 16
NO - Norvegia 16
SK - Slovacchia (Repubblica Slovacca) 16
TH - Thailandia 16
YT - Mayotte 16
ZM - Zambia 16
AD - Andorra 15
AO - Angola 15
Totale 15.720
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Città #
Ashburn 1.072
Singapore 827
San Jose 717
Fairfield 636
Ann Arbor 471
Chandler 432
Woodbridge 427
Houston 341
Hong Kong 316
Cambridge 297
Jacksonville 262
Seattle 262
Wilmington 244
Santa Clara 217
Ho Chi Minh City 201
Beijing 186
Council Bluffs 167
Hanoi 167
Los Angeles 139
Boardman 120
Padova 106
Princeton 99
New York 84
Lauterbourg 70
Milan 57
San Diego 55
Helsinki 53
Medford 53
Des Moines 49
Munich 47
Nanjing 47
Buffalo 45
Bytom 45
Chicago 45
São Paulo 42
Dallas 41
Rome 41
Da Nang 40
Haiphong 33
Montreal 32
Orem 32
Tokyo 32
London 31
Johannesburg 29
Pune 27
Cotonou 26
Stockholm 25
Amman 24
Baku 24
Brooklyn 24
Buenos Aires 24
Denver 23
Shanghai 23
Guangzhou 22
Tashkent 22
Abidjan 21
Hefei 21
Hyderabad 21
Managua 21
Paris 21
Vienna 21
Warsaw 21
Amsterdam 20
Kingston 20
Nairobi 20
Atlanta 19
Bishkek 19
Boston 19
Dong Ket 19
Dublin 19
Dushanbe 19
Panama City 19
Phoenix 19
San José 19
The Dalles 19
Changsha 18
Conakry 18
Poplar 18
Shenyang 18
Baghdad 17
Frankfurt am Main 17
Manchester 17
Nouakchott 17
Podgorica 17
Sydney 17
Zurich 16
Andorra la Vella 15
Bridgetown 15
Castries 15
Dakar 15
Jeddah 15
Libreville 15
Lima 15
Lusaka 15
Nanchang 15
Quito 15
Antananarivo 14
Belo Horizonte 14
Dar es Salaam 14
Gaborone 14
Totale 9.766
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Nome #
Flavonoids diosmetin and luteolin inhibit midazolam metabolism by human liver microsomes and recombinant CYP 3A4 and CYP3A5 enzymes 468
Ethylene negatively regulates transcript abundance of ROP-GAP rheostat-encoding genes and affects apoplastic reactive oxygen species homeostasis in epicarps of cold stored apple fruits 406
Evaluating the effects of fluorine on biological properties and metabolic stability of some antitubulin 3-substituted 7-phenyl-pyrroloquinolinones 382
Cellular pharmacology of PNU-159682, a liver microsomal metabolite of methoxymorpholinyl doxorubicin (Nemorubicin; MMDX) 334
Formation and antitumor activity of PNU-159682, a major metabolite of nemorubicin in human liver microsomes 322
Synthesis, structure-activity relationships and biological evaluation of 7-phenyl-pyrroloquinolinone 3-amide derivatives as potent antimitotic agents 320
Synthesis and characterisation of a new benzamide-containing nitrobenzoxadiazole as a GSTP1-1 inhibitor endowed with high stability to metabolic hydrolysis 310
A paclitaxel-hyaluronan bioconjugate targeting ovarian cancer affords a potent in vivo therapeutic activity. 306
Prolonging the stability of cetuximab (Erbitux®) and panitumumab (Vectibix®): An orthogonal assessment of physicochemical, biological and microbiological properties of original opened glass vials and diluted saline preparations 295
Overcoming Cancer Cell Drug Resistance by a Folic Acid Targeted Polymeric Conjugate of Buthionine Sulfoximine 271
Flavonoids diosmetin and hesperetin are potent inhibitors of cytochrome P450 2C9-mediated drug metabolism in vitro. 269
LKB1 loss is associated with glutathione deficiency under oxidative stress and sensitivity of cancer cells to cytotoxic drugs and γ-irradiation 267
Virtual Cross-Linking of the Active Nemorubicin Metabolite PNU-159682 to Double-Stranded DNA 260
Relative contribution of cytochrome P450 3A to midazolam oxidation in cattle liver microsomes. 259
Hyperthermic isolated perfusion with low-dose tumor necrosis factor alpha and doxorubicin for the treatment of limb-threatening soft tissue sarcomas. 258
The nitrobenzoxadiazole derivative MC3181 blocks melanoma invasion and metastasis 258
Thiol-Activated Anticancer Agents: The State of the Art 257
In vitro evidence that carteolol is a nonconventional partial agonist of guinea pig cardiac beta1-adrenoceptors: a comparison with xamoterol. 255
Determinants of Drug Resistance in B-Cell Non-Hodgkin Lymphomas: The Case of Lymphoplasmacytic Lymphoma/Waldenström Macroglobulinemia 253
In vitro hepatic conversion of the anticancer agent nemorubicin to its active metabolite PNU-159682 in mice, rats and dogs: A comparison with human liver microsomes 249
R-warfarin anticoagulant effect 248
Cell-secreted vesicles: Novel opportunities in cancer diagnosis, monitoring and treatment 246
Fluorescent, internally quenced, peptides for exploring the pH-dependent substrate specificity of cathepsin B 242
Characterization of water-soluble esters of nitrobenzoxadiazole-based GSTP1-1 inhibitors for cancer treatment 242
Glutathione transferases as targets for cancer therapy. 240
A novel orally active water-soluble inhibitor of human glutathione transferase exerts a potent and selective antitumor activity against human melanoma xenografts 237
Sex-related differences in renal toxicodynamics in rodents 235
Quantitative Prediction of Drug Interactions Caused by Cytochrome P450 2B6 Inhibition or Induction 230
Midazolam oxidation in cattle liver microsomes: The role of cytochrome P450 3A 225
Design and synthesis of a tripartate paclitaxel prodrug for melanoma therapy 221
Synthesis and preliminary in vitro biological evaluation of 4-[(4-hydroxyphenyl)sulfanyl]but-3-en-2-one, a 4-mercaptophenol derivative designed as a novel bifunctional antimelanoma agent. 215
Inhibition of cytochrome P450 2C8-mediated drug metabolism by the flavonoid diosmetin. 213
Pentoxifylline and its major oxidative metabolites exhibit different pharmacological properties 209
Metabolismo del diclofenac in una linea cellulare stabilizzata di Catharanthus roseus 209
Delivery of methoxymorpholinyl doxorubicin by interleukin 2-activated NK cells: effect in mice bearing hepatic metastases 202
Therapeutic effect of interleukin 12 on mouse haemangiosarcomas is not associated with an increased anti-tumour cytotoxic T-lymphocyte activity 201
Identification of Molecular Determinants of Tumor Sensitivity and Resistance to Anticancer Drugs 200
A genetic algorithm-based approach for the prediction of metabolic drug-drug interactions involving CYP2C8 or CYP2B6 197
Irreversible CYP3A Inhibition Accompained by Plasma Protein-Binding Displacement: A Comparative Analysis in Subjects with normal and impaired liver function. 197
A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability 193
Screening of sulfasalazine analogues for inhibition of human glutathione transferase P1-1, a target for anticancer therapy 192
Vanillin analogues o-vanillin and 2,4,6-trihydroxybenzaldehyde inhibit NFκB activation and suppress growth of A375 human melanoma 192
Gender and species differences in hepatic conversion of Nemorubicin to its highly cytotoxic metabolite, PNU-159682 191
In vitro inhibition of cytochrome P450 (CYP) 2C8-mediated drug metabolism by the flavonoid diosmetin 190
The Nitrobenzoxadiazole Derivative NBDHEX Behaves as Plasmodium falciparum Gametocyte Selective Inhibitor with Malaria Parasite Transmission Blocking Activity 182
Polysialic acid as a drug carrier: evaluation of a new polysialic acid–epirubicin conjugate and its comparison against established drug carriers 181
A Quantitative Approach to the Prediction of Drug-Drug Interactions Mediated by Cytochrome P450 2C8 Inhibition 179
CD45 regulates apoptosis induced by extracellular adenosine triphosphate and cytotoxic T lymphocytes 178
Comparison of the binding affinity of CGP-12177A at recombinant rat alpha(1D)-adrenoceptors expressed in BHK-21 cell membranes and alpha(1)-adrenoceptors present in rat cerebral cortex membranes 177
Olopatadine: a drug for allergic conjunctivitis targeting the mast cell 174
Initial in vitro interspecies comparison of hepatic metabolism of the investigational anticancer agent 6-(7-nitro-2,1,3-benzoxadiazol-4- ylthio)hexanol (NBDHEX) 174
Carteolol, a non-conventional partial agonist of beta(1)-adrenoceptors, relaxes phenylephrine-constricted rat aorta through antagonism at alpha(1)-adrenoceptors 173
Insights into the cellular pharmacokinetics and pharmacodynamics of thiopurine antimetabolites in a model of human intestinal cells 173
4-[(4'-idrossifenil)sulfanil]-3-buten-2-one (HPSBO), un potenziale "lead" per losviluppo di agenti bifunzionali per la terapia mirata del melanoma 172
Hyperthermic isolated perfusion with low-dose TNFalpha and doxorubicin in patients with locally advanced soft tissue limb sarcomas. 171
Pharmacokinetics of intraperitoneal cisplatin and doxorubicin 168
Design and synthesis of a tripartate paclitaxel prodrug for melanoma therapy. 167
Cytochrome P450 3A4 mediates transformation of methoxymorpholinyl doxorubicin (Nemorubicin; MMDX) to highly potent metabolite PNU-159682 in human liver microsomes 166
Oral administration of trans-resveratrol to guinea pigs increases cardiac DT-diaphorase and catalase activities, and protects isolated atria from menadione toxicity 158
Anti-Cancer Agents in Medicinal Chemistry: Editorial 158
Cancer gene therapy by DNA immunization 157
Evaluation of inhibitory activity and selectivity of novel sulfasalazine analogues towards human glutathione transferases 156
Initial characterization of the metabolic stability of the selective and potent glutathione transferase P1-1 inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) in liver microsomes and cytosol: an interspecies comparison 155
In vitro and in vivo antitumor activity of nemorubicin metabolites 152
Nemorubicin: a third-generation anthracycline active on hepatocellularr carcinoma (HCC) 151
Allergic Conjunctivitis Management: Update on Ophthalmic Solutions 147
Binding and reactivity towards DNA of PNU-159682, the highly cytotoxic metabolite of nemorubicin 147
Antitumors DNA vaccines [Vaccini antitumorali a DNA] 141
Metabolic effects of antiangiogenic drugs in tumors: Therapeutic implications 141
Characterization of the interaction with nucleic acids of the highly cytotoxic oxidative metabolite of the anthracycline nemorubicin by fluorescence quenching assays 137
Enzymes as useful tools and potential targets in cancer chemotherapy. Editorial 133
In vivo antitumor activity and host toxicity of methoxymorpholinyl doxorubicin: Role of cytochrome P450 3A 128
Development of a rapid reverse-phase HPLC method for the phenotypic analysis of gemcitabine deamination 120
A genetic algorithm-based approach for quantitative prediction of drug-drug interactions caused by cytochrome P450 3A inhibitors and inducers in dogs and cats 119
Methoxymorpholinyl doxorubicin (PNU152243) antitumor activity in vivo: Involvement of cytochrome P450 (CYP)-mediated drug metabolism 119
Sensitivity of different cell lines to nemorubicin and its metabolites 115
Nemorubicin synergizes with agents currently used for the treatment of hepatocellular carcinoma (HCC) 111
Preclinical activity against metastases of Nemorubicin, a DNA-intercalating cytotoxic agent for the treatment of hepatocellular carcinoma 101
Nucleotide excision repair (NER) plays a central role in the mechanism of action of nemorubicin: Silencing of XPG as a mechanism of resistance 99
Nemorubicin: A doxorubicin-like structure with a novel mechanism of action different from anthracyclines. 89
Development of an Empirical Approach for the Prediction of Cytochrome P450-Based Drug-Drug Interactions in Pediatric Patients 11
A Genetic Algorithm-Based Approach for Quantitative Prediction of Drug-Drug Interactions Caused by Cytochrome P450 3A Inhibition or Induction in Horses 8
Uptake and biotransformation of paracetamol by three lettuce varieties (Lactuca sativa L.) 6
Totale 16.560
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Categoria #
all - tutte 45.346
article - articoli 36.921
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 610
Totale 82.877
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022800 0 0 135 62 36 67 19 127 39 19 86 210
2022/2023835 119 85 19 101 150 127 1 68 116 10 22 17
2023/2024485 39 72 47 27 28 78 52 21 14 17 44 46
2024/20252.003 29 161 118 90 289 94 68 208 125 77 277 467
2025/20268.075 425 635 972 1.219 798 335 1.109 663 750 457 346 366
2026/2027842 462 354 26 0 0 0 0 0 0 0 0 0
Totale 16.560