QUINTIERI, LUIGI
 Distribuzione geografica
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Continente #
NA - Nord America 6.095
AS - Asia 2.663
EU - Europa 1.535
SA - Sud America 618
AF - Africa 588
OC - Oceania 75
Continente sconosciuto - Info sul continente non disponibili 31
Totale 11.605
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Nazione #
US - Stati Uniti d'America 5.783
SG - Singapore 941
CN - Cina 585
BR - Brasile 357
IT - Italia 286
HK - Hong Kong 238
VN - Vietnam 208
DE - Germania 159
FI - Finlandia 116
GB - Regno Unito 86
SE - Svezia 85
FR - Francia 79
IN - India 79
AR - Argentina 74
PL - Polonia 71
UA - Ucraina 67
RU - Federazione Russa 62
NL - Olanda 57
ZA - Sudafrica 40
KR - Corea 36
EC - Ecuador 32
JP - Giappone 32
ID - Indonesia 31
AT - Austria 30
TR - Turchia 30
CL - Cile 28
MX - Messico 28
AE - Emirati Arabi Uniti 27
CA - Canada 27
CO - Colombia 26
IR - Iran 26
AU - Australia 25
BJ - Benin 25
CH - Svizzera 25
DZ - Algeria 25
MY - Malesia 24
AZ - Azerbaigian 23
BO - Bolivia 23
BZ - Belize 22
DK - Danimarca 22
ES - Italia 21
CI - Costa d'Avorio 20
GR - Grecia 20
IE - Irlanda 20
PK - Pakistan 20
PS - Palestinian Territory 20
TJ - Tagikistan 20
TN - Tunisia 20
HR - Croazia 19
IL - Israele 19
IQ - Iraq 19
ME - Montenegro 19
PE - Perù 19
UZ - Uzbekistan 19
VE - Venezuela 19
BG - Bulgaria 18
ET - Etiopia 18
GN - Guinea 18
KG - Kirghizistan 18
KZ - Kazakistan 18
MR - Mauritania 18
NI - Nicaragua 18
NP - Nepal 18
PA - Panama 18
TZ - Tanzania 18
AL - Albania 17
JM - Giamaica 17
LC - Santa Lucia 17
MA - Marocco 17
PR - Porto Rico 17
RS - Serbia 17
BE - Belgio 16
GF - Guiana Francese 16
LB - Libano 16
LV - Lettonia 16
LY - Libia 16
NO - Norvegia 16
PH - Filippine 16
SK - Slovacchia (Repubblica Slovacca) 16
TW - Taiwan 16
YT - Mayotte 16
AD - Andorra 15
AO - Angola 15
BB - Barbados 15
BD - Bangladesh 15
BW - Botswana 15
CY - Cipro 15
CZ - Repubblica Ceca 15
GT - Guatemala 15
IS - Islanda 15
JO - Giordania 15
MG - Madagascar 15
RW - Ruanda 15
ZM - Zambia 15
BF - Burkina Faso 14
GA - Gabon 14
HN - Honduras 14
KE - Kenya 14
LU - Lussemburgo 14
MZ - Mozambico 14
Totale 10.955
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Città #
Ashburn 661
Fairfield 636
Singapore 520
Ann Arbor 471
Chandler 432
Woodbridge 427
Houston 331
Cambridge 297
Jacksonville 258
Seattle 256
Wilmington 244
Hong Kong 222
Beijing 179
Santa Clara 177
Boardman 117
Padova 106
Princeton 97
Los Angeles 65
Ho Chi Minh City 61
San Diego 54
Medford 52
Des Moines 49
Munich 47
Nanjing 47
Bytom 45
Helsinki 41
New York 40
Hanoi 38
São Paulo 29
Buffalo 27
Cotonou 25
Pune 25
Johannesburg 22
London 22
Stockholm 22
Baku 21
Brooklyn 21
Buenos Aires 21
Hefei 21
Chicago 20
Tokyo 20
Vienna 20
Abidjan 19
Dong Ket 19
Dushanbe 19
Conakry 18
Panama City 18
Shenyang 18
Bishkek 17
Hyderabad 17
Podgorica 17
Shanghai 17
Dublin 16
Managua 16
Milan 16
Nouakchott 16
Amman 15
Andorra la Vella 15
Bridgetown 15
Castries 15
Lima 15
Nanchang 15
Sydney 15
Tashkent 15
Antananarivo 14
Boston 14
Changsha 14
Dakar 14
Dar es Salaam 14
Denver 14
Guangzhou 14
Kigali 14
Libreville 14
Luanda 14
Lusaka 14
Montreal 14
Redwood City 14
Riga 14
Warsaw 14
Jinan 13
Nairobi 13
Noumea 13
Port Moresby 13
Rome 13
Bamako 12
Cayenne 12
Gaborone 12
Havana 12
Kingston 12
La Paz 12
Mamoudzou 12
Nassau 12
Paris 12
Belize City 11
Guayaquil 11
Haiphong 11
Jiaxing 11
Manchester 11
Norwalk 11
Poplar 11
Totale 7.109
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Nome #
Ethylene negatively regulates transcript abundance of ROP-GAP rheostat-encoding genes and affects apoplastic reactive oxygen species homeostasis in epicarps of cold stored apple fruits 265
Cellular pharmacology of PNU-159682, a liver microsomal metabolite of methoxymorpholinyl doxorubicin (Nemorubicin; MMDX) 264
Synthesis and characterisation of a new benzamide-containing nitrobenzoxadiazole as a GSTP1-1 inhibitor endowed with high stability to metabolic hydrolysis 256
Evaluating the effects of fluorine on biological properties and metabolic stability of some antitubulin 3-substituted 7-phenyl-pyrroloquinolinones 252
A paclitaxel-hyaluronan bioconjugate targeting ovarian cancer affords a potent in vivo therapeutic activity. 242
Synthesis, structure-activity relationships and biological evaluation of 7-phenyl-pyrroloquinolinone 3-amide derivatives as potent antimitotic agents 230
The nitrobenzoxadiazole derivative MC3181 blocks melanoma invasion and metastasis 214
In vitro hepatic conversion of the anticancer agent nemorubicin to its active metabolite PNU-159682 in mice, rats and dogs: A comparison with human liver microsomes 212
Formation and antitumor activity of PNU-159682, a major metabolite of nemorubicin in human liver microsomes 208
Prolonging the stability of cetuximab (Erbitux®) and panitumumab (Vectibix®): An orthogonal assessment of physicochemical, biological and microbiological properties of original opened glass vials and diluted saline preparations 204
Virtual Cross-Linking of the Active Nemorubicin Metabolite PNU-159682 to Double-Stranded DNA 202
Flavonoids diosmetin and luteolin inhibit midazolam metabolism by human liver microsomes and recombinant CYP 3A4 and CYP3A5 enzymes 198
R-warfarin anticoagulant effect 198
Hyperthermic isolated perfusion with low-dose tumor necrosis factor alpha and doxorubicin for the treatment of limb-threatening soft tissue sarcomas. 194
Overcoming Cancer Cell Drug Resistance by a Folic Acid Targeted Polymeric Conjugate of Buthionine Sulfoximine 192
Flavonoids diosmetin and hesperetin are potent inhibitors of cytochrome P450 2C9-mediated drug metabolism in vitro. 190
Thiol-Activated Anticancer Agents: The State of the Art 187
In vitro evidence that carteolol is a nonconventional partial agonist of guinea pig cardiac beta1-adrenoceptors: a comparison with xamoterol. 187
LKB1 loss is associated with glutathione deficiency under oxidative stress and sensitivity of cancer cells to cytotoxic drugs and γ-irradiation 186
Sex-related differences in renal toxicodynamics in rodents 182
Glutathione transferases as targets for cancer therapy. 175
A novel orally active water-soluble inhibitor of human glutathione transferase exerts a potent and selective antitumor activity against human melanoma xenografts 173
Midazolam oxidation in cattle liver microsomes: The role of cytochrome P450 3A 168
Relative contribution of cytochrome P450 3A to midazolam oxidation in cattle liver microsomes. 160
Inhibition of cytochrome P450 2C8-mediated drug metabolism by the flavonoid diosmetin. 160
Synthesis and preliminary in vitro biological evaluation of 4-[(4-hydroxyphenyl)sulfanyl]but-3-en-2-one, a 4-mercaptophenol derivative designed as a novel bifunctional antimelanoma agent. 160
Delivery of methoxymorpholinyl doxorubicin by interleukin 2-activated NK cells: effect in mice bearing hepatic metastases 156
Pentoxifylline and its major oxidative metabolites exhibit different pharmacological properties 155
Identification of Molecular Determinants of Tumor Sensitivity and Resistance to Anticancer Drugs 154
A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability 152
Characterization of water-soluble esters of nitrobenzoxadiazole-based GSTP1-1 inhibitors for cancer treatment 152
Gender and species differences in hepatic conversion of Nemorubicin to its highly cytotoxic metabolite, PNU-159682 151
Determinants of Drug Resistance in B-Cell Non-Hodgkin Lymphomas: The Case of Lymphoplasmacytic Lymphoma/Waldenström Macroglobulinemia 148
Irreversible CYP3A Inhibition Accompained by Plasma Protein-Binding Displacement: A Comparative Analysis in Subjects with normal and impaired liver function. 142
Design and synthesis of a tripartate paclitaxel prodrug for melanoma therapy 140
Fluorescent, internally quenced, peptides for exploring the pH-dependent substrate specificity of cathepsin B 140
Pharmacokinetics of intraperitoneal cisplatin and doxorubicin 139
Screening of sulfasalazine analogues for inhibition of human glutathione transferase P1-1, a target for anticancer therapy 139
Olopatadine: a drug for allergic conjunctivitis targeting the mast cell 137
CD45 regulates apoptosis induced by extracellular adenosine triphosphate and cytotoxic T lymphocytes 137
Vanillin analogues o-vanillin and 2,4,6-trihydroxybenzaldehyde inhibit NFκB activation and suppress growth of A375 human melanoma 137
In vitro and in vivo antitumor activity of nemorubicin metabolites 134
Therapeutic effect of interleukin 12 on mouse haemangiosarcomas is not associated with an increased anti-tumour cytotoxic T-lymphocyte activity 134
Polysialic acid as a drug carrier: evaluation of a new polysialic acid–epirubicin conjugate and its comparison against established drug carriers 134
A genetic algorithm-based approach for the prediction of metabolic drug-drug interactions involving CYP2C8 or CYP2B6 132
Hyperthermic isolated perfusion with low-dose TNFalpha and doxorubicin in patients with locally advanced soft tissue limb sarcomas. 131
Cell-secreted vesicles: Novel opportunities in cancer diagnosis, monitoring and treatment 131
Cancer gene therapy by DNA immunization 130
Nemorubicin: a third-generation anthracycline active on hepatocellularr carcinoma (HCC) 128
Initial in vitro interspecies comparison of hepatic metabolism of the investigational anticancer agent 6-(7-nitro-2,1,3-benzoxadiazol-4- ylthio)hexanol (NBDHEX) 128
Oral administration of trans-resveratrol to guinea pigs increases cardiac DT-diaphorase and catalase activities, and protects isolated atria from menadione toxicity 128
4-[(4'-idrossifenil)sulfanil]-3-buten-2-one (HPSBO), un potenziale "lead" per losviluppo di agenti bifunzionali per la terapia mirata del melanoma 127
Comparison of the binding affinity of CGP-12177A at recombinant rat alpha(1D)-adrenoceptors expressed in BHK-21 cell membranes and alpha(1)-adrenoceptors present in rat cerebral cortex membranes 127
A Quantitative Approach to the Prediction of Drug-Drug Interactions Mediated by Cytochrome P450 2C8 Inhibition 126
Cytochrome P450 3A4 mediates transformation of methoxymorpholinyl doxorubicin (Nemorubicin; MMDX) to highly potent metabolite PNU-159682 in human liver microsomes 125
Carteolol, a non-conventional partial agonist of beta(1)-adrenoceptors, relaxes phenylephrine-constricted rat aorta through antagonism at alpha(1)-adrenoceptors 122
Binding and reactivity towards DNA of PNU-159682, the highly cytotoxic metabolite of nemorubicin 115
Anti-Cancer Agents in Medicinal Chemistry: Editorial 115
Design and synthesis of a tripartate paclitaxel prodrug for melanoma therapy. 114
Insights into the cellular pharmacokinetics and pharmacodynamics of thiopurine antimetabolites in a model of human intestinal cells 112
Initial characterization of the metabolic stability of the selective and potent glutathione transferase P1-1 inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) in liver microsomes and cytosol: an interspecies comparison 111
Evaluation of inhibitory activity and selectivity of novel sulfasalazine analogues towards human glutathione transferases 111
Metabolismo del diclofenac in una linea cellulare stabilizzata di Catharanthus roseus 111
Antitumors DNA vaccines [Vaccini antitumorali a DNA] 110
The Nitrobenzoxadiazole Derivative NBDHEX Behaves as Plasmodium falciparum Gametocyte Selective Inhibitor with Malaria Parasite Transmission Blocking Activity 109
Characterization of the interaction with nucleic acids of the highly cytotoxic oxidative metabolite of the anthracycline nemorubicin by fluorescence quenching assays 107
Quantitative Prediction of Drug Interactions Caused by Cytochrome P450 2B6 Inhibition or Induction 106
In vitro inhibition of cytochrome P450 (CYP) 2C8-mediated drug metabolism by the flavonoid diosmetin 99
Metabolic effects of antiangiogenic drugs in tumors: Therapeutic implications 99
Enzymes as useful tools and potential targets in cancer chemotherapy. Editorial 99
Methoxymorpholinyl doxorubicin (PNU152243) antitumor activity in vivo: Involvement of cytochrome P450 (CYP)-mediated drug metabolism 98
Development of a rapid reverse-phase HPLC method for the phenotypic analysis of gemcitabine deamination 92
Allergic Conjunctivitis Management: Update on Ophthalmic Solutions 91
Sensitivity of different cell lines to nemorubicin and its metabolites 90
Nemorubicin synergizes with agents currently used for the treatment of hepatocellular carcinoma (HCC) 84
Preclinical activity against metastases of Nemorubicin, a DNA-intercalating cytotoxic agent for the treatment of hepatocellular carcinoma 79
In vivo antitumor activity and host toxicity of methoxymorpholinyl doxorubicin: Role of cytochrome P450 3A 78
Nucleotide excision repair (NER) plays a central role in the mechanism of action of nemorubicin: Silencing of XPG as a mechanism of resistance 75
A genetic algorithm-based approach for quantitative prediction of drug-drug interactions caused by cytochrome P450 3A inhibitors and inducers in dogs and cats 68
Nemorubicin: A doxorubicin-like structure with a novel mechanism of action different from anthracyclines. 58
Totale 11.706
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Categoria #
all - tutte 34.914
article - articoli 28.531
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 504
Totale 63.949
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021662 0 0 0 0 0 96 15 68 136 162 98 87
2021/2022910 7 103 135 62 36 67 19 127 39 19 86 210
2022/2023835 119 85 19 101 150 127 1 68 116 10 22 17
2023/2024485 39 72 47 27 28 78 52 21 14 17 44 46
2024/20252.003 29 161 118 90 289 94 68 208 125 77 277 467
2025/20264.063 425 635 972 1.219 798 14 0 0 0 0 0 0
Totale 11.706