In a preliminary cohort of children recovering from asymptomatic or mild coronavirus disease 2019, subclinical cardiac contractility alterations were associated with reduced regulatory T cells, shorter telomeres and elevated inflammatory markers 3 months post-infection. These findings suggest that immune dysregulation may contribute to silent post-coronavirus disease 2019 cardiac dysfunction and warrant confirmation in larger cohorts with long-term follow-up.
Impaired Treg Response and Subclinical Cardiac Dysfunction in Children Following SARS-CoV-2 Infection
Di Chiara, Costanza;Sabatino, Jolanda;Dona', Daniele;De Rossi, Anita;Di Salvo, Giovanni;Giaquinto, Carlo
2026
Abstract
In a preliminary cohort of children recovering from asymptomatic or mild coronavirus disease 2019, subclinical cardiac contractility alterations were associated with reduced regulatory T cells, shorter telomeres and elevated inflammatory markers 3 months post-infection. These findings suggest that immune dysregulation may contribute to silent post-coronavirus disease 2019 cardiac dysfunction and warrant confirmation in larger cohorts with long-term follow-up.
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