Editorial: Zebrafish: bona fide pathophysiological models of human diseases

The zebrafish (Danio rerio) has emerged as a pivotal vertebrate model in biomedical research, occupying a unique position at the intersection of developmental biology, disease modeling, and translational medicine. With remarkable genetic conservation, optical transparency, rapid embryonic development, and a rich repertoire of genetic tools, zebrafish are now extensively employed to unravel the molecular and cellular mechanisms underlying a broad range of human diseases. This Research Topic gathers a compelling set of eight studies that illustrate the versatility and power of zebrafish in modeling human pathophysiology across diverse organ systems.