International prevalence patterns of low eGFR in adults aged 18-60 without traditional risk factors from a population-based cross-sectional disadvantaged populations eGFR epidemiology (DEGREE) study

Rutter, C. E.; Njoroge, M.; Cooper, P. J.; Prabhakaran, D.; Jha, V.; Kaur, P.; Mohan, S.; Tatapudi, R. R.; Biggeri, A.; Rohloff, P.; Hathaway, M. H.; Crampin, A. C.; Dhimal, M.; Poudyal, A.; Bernabe-Ortiz, A.; O'Callaghan-Gordo, C.; Chulasiri, P.; Gunawardena, N.; Ruwanpathirana, T.; Wickramasinghe, S. C.; Senanayake, S.; Kitiyakara, C.; Gonzalez-Quiroz, M.; Cortés, S.; Jakobsson, K.; Correa-Rotter, R.; Glaser, J.; Singh, A.; Hamilton, S.; Nair, D.; Aragón, A.; Nitsch, D.; Robertson, S.; Caplin, B.; Pearce, N.; Aekplakorn, W.; Anand, S.; Aragón, A.; Bernabe-Ortiz, A.; Biggeri, A.; Burdmann, E.; Caplin, B.; Catelan, D.; Cooper, P. J.; Cortés, S.; Crampin, A. C.; De Santiago, M.; Dhimal, M.; Doccioli, C.; Dorevitch, S.; Ferreccio, C.; Glaser, J.; Gonzalez-Quiroz, M.; Granadillo, E.; Gualan, M.; Gummidi, B.; Gunawardena, N.; Hamilton, S.; Hathaway, M. H.; Jakobsson, K.; Jarhyan, P.; Jha, V.; John, O.; Johnson, R. J.; Kaur, P.; Kitiyakara, C.; Kongtip, P.; Kromhout, H.; Levin, A.; Madero, M.; Mclean, E.; Miranda, J. J.; Mkandawire, J.; Mohan, S.; Murali, S.; Nair, D.; Nakanga, W.; Nitsch, D.; Njoroge, M.; Nyirenda, M.; O'Callaghan-Gordo, C.; Pearce, N.; Poudyal, A.; Prabhakaran, D.; Prasad, N.; Quirós-Alcalá, L.; Remuzzi, G.; Robertson, S.; Rohloff, P.; Romero-Sandoval, N.; Ruiz-Alejos, A.; Rutter, C. E.; Ruwanpathirana, T.; Sakthivel, M.; Saran, R.; Senanayake, S.; Shaw, L.; Singh, A.; Smeeth, L.; Sotomayor, C.

doi:10.1016/j.kint.2024.11.028

The disadvantaged populations eGFR (estimated glomerular filtration rate) epidemiology (DEGREE) study was designed to gain insight into the burden of chronic kidney disease (CKD) of undetermined cause (CKDu) using standard protocols to estimate the general-population prevalence of low eGFR internationally. Therefore, we estimated the age-standardized prevalence of eGFR under 60 ml/min per 1.73m2 in adults aged 18-60, excluding participants with commonly known causes of CKD; an ACR (albumin/creatinine ratio) over 300 mg/g or equivalent, or self-reported or measured (HT) hypertension or (DM) diabetes mellitus, stratified by sex and location. We included population-representative surveys conducted around the world that were either designed to estimate CKDu burden or were re-analyses of large surveys. There were 60,964 participants from 43 areas across 14 countries, with data collected 2007- 2023. The highest prevalence was seen in rural men in Uddanam, India (14%) and Northwest Nicaragua ...