Impact of diffusion connectivity metrics on white matter abnormalities in glioma

Structural connectivity (SC) matrix of brain tumours is usually quantified by number of streamlines (NOS) of tracts connecting regions of interest. Several are the limitations linked to this weight. This study aims to investigate the impact of different connectome metrics by evaluating the white matter abnormalities. We found that diffusion microstructure parameters provide higher and spatially different alterations with respect to NOS. With this fact, we can enrich the NOS-based connectivity integrating diffusion microstructure properties.