Apart from the still-discussed extra-skeletal effects, vitamin D plays a key role in calcium and phosphate homeostasis and its deficiency is associated with bone disorders such as rickets, osteomalacia and the increased risk of osteoporotic fractures. 25-hydroxy vitamin D [25-(OH)D] is the circulating metabolite commonly used as a marker of vitamin D status.The aim of this document is to express, on the basis of the available guidelines, an Intersociety consensus on how to report the values of the main marker of vitamin D status: 25-hydroxy vitamin D [25-(OH)D]. The main points of this proposal are: to use nmol/L as the measurement units, to measure the analyte at the end of winter/beginning of summer, and to consider an analytical variability of ±10%. In addition, the decision levels to be reported in the report are agreed upon.
Proposal for the reporting of vitamin D determination
Giannini S.;Lombardi G.
2024
Abstract
Apart from the still-discussed extra-skeletal effects, vitamin D plays a key role in calcium and phosphate homeostasis and its deficiency is associated with bone disorders such as rickets, osteomalacia and the increased risk of osteoporotic fractures. 25-hydroxy vitamin D [25-(OH)D] is the circulating metabolite commonly used as a marker of vitamin D status.The aim of this document is to express, on the basis of the available guidelines, an Intersociety consensus on how to report the values of the main marker of vitamin D status: 25-hydroxy vitamin D [25-(OH)D]. The main points of this proposal are: to use nmol/L as the measurement units, to measure the analyte at the end of winter/beginning of summer, and to consider an analytical variability of ±10%. In addition, the decision levels to be reported in the report are agreed upon.
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