While skeletal editing stands as a powerful approach for simplifying synthetic procedures and obtaining complex molecules, viable methodologies remain limited. Now, a smart photoredox protocol, involving the insertion of carbon atoms into the indene core, gives access to a wide library of functionalized naphthalenes.
Drug design via single-carbon atom insertion
Sicignano, Marina;
2024
Abstract
While skeletal editing stands as a powerful approach for simplifying synthetic procedures and obtaining complex molecules, viable methodologies remain limited. Now, a smart photoredox protocol, involving the insertion of carbon atoms into the indene core, gives access to a wide library of functionalized naphthalenes.
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