New family monothiooxalamides containing pyridine moiety were synthesized. The structures of monoth-iooxalamides were confirmed by one-dimension NMR experiments H-1 and C-13, and 2D NMR (COSY, HSQC, and HMBC). In addition, antiproliferative activity was evaluated in human cancer cell lines. One com-pound showed antiproliferative effects against human tumor cell lines. Furthermore, the cytotoxic com-pound showed the ability to induce a Reactive Oxygen Species (ROS) production on the A2780-wt cell line. This study discarded the substitution pattern of non-active and allowed to identify the structure that could be used as a scaffold for the future design of monothiooxalamides with promising antipro-liferative capability. Moreover, the in vitro antioxidant activity was determined by DPPH center dot , ABTS center dot(+), FRAP, ORAC, and the Fe(II) chelating ability assays. Additionally, the antiradical potential was determined the-oretically employing Donor-Acceptor Maps (DAM), and the function was used to estimate the reactive regions involved in this process. (C) 2022 Elsevier B.V. All rights reserved.
Synthesis and characterization of new monothiooxalamides containing pyridine nuclei with promising antiproliferative and antioxidant activity
Dalla Via, L;
2022
Abstract
New family monothiooxalamides containing pyridine moiety were synthesized. The structures of monoth-iooxalamides were confirmed by one-dimension NMR experiments H-1 and C-13, and 2D NMR (COSY, HSQC, and HMBC). In addition, antiproliferative activity was evaluated in human cancer cell lines. One com-pound showed antiproliferative effects against human tumor cell lines. Furthermore, the cytotoxic com-pound showed the ability to induce a Reactive Oxygen Species (ROS) production on the A2780-wt cell line. This study discarded the substitution pattern of non-active and allowed to identify the structure that could be used as a scaffold for the future design of monothiooxalamides with promising antipro-liferative capability. Moreover, the in vitro antioxidant activity was determined by DPPH center dot , ABTS center dot(+), FRAP, ORAC, and the Fe(II) chelating ability assays. Additionally, the antiradical potential was determined the-oretically employing Donor-Acceptor Maps (DAM), and the function was used to estimate the reactive regions involved in this process. (C) 2022 Elsevier B.V. All rights reserved.
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