[Amelanotic acral melanoma originating from the foot: a clinical case.]

We will present the case of a 75-year-old woman diagnosed with an amelanotic acral melanoma originating from the left foot relapsed to the lung and to muscular and subcutaneous tissues less than one year after the surgical treatment (pT4bN3c, AJCC 8th ed.) of the primary lesion. Treated with first-line encorafenib + binimetinib, the patient reported a complete response lasting 37 months and followed by a partial response, still ongoing after 19 months, to anti-PD-1 antibody second line therapy.