Microglia, the resident immune cell of the brain and retina, is widespread activated in the white and gray matter (GM) in multiple sclerosis (MS). The objective of this study is to evaluate the presence and number of hyperreflecting foci (HRF), considered clusters of activated and proliferating retinal microglia, and their association with clinical and radiologic disease parameters in relapsing-remitting MS (RRMS).
Retinal Hyperreflecting Foci Associate With Cortical Pathology in Multiple Sclerosis
Pengo, Marta;Miante, Silvia;Franciotta, Silvia;Torresin, Tommaso;Saiani, Martina;Margoni, Monica;Bertoldo, Alessandra;Pilotto, Elisabetta;Midena, Edoardo;Gallo, Paolo;Puthenparampil, Marco
2022
Abstract
Microglia, the resident immune cell of the brain and retina, is widespread activated in the white and gray matter (GM) in multiple sclerosis (MS). The objective of this study is to evaluate the presence and number of hyperreflecting foci (HRF), considered clusters of activated and proliferating retinal microglia, and their association with clinical and radiologic disease parameters in relapsing-remitting MS (RRMS).
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