Ectopic calcification is a typical feature of diabetic vascular disease and resembles an accelerated ageing phenotype. We previously found an excess of myeloid calcifying cells in diabetic individuals. We herein examined molecular and cellular pathways linking atherosclerotic calcification with calcification by myeloid cells in the diabetic milieu.
A miR-125/Sirtuin-7 pathway drives the pro-calcific potential of myeloid cells in diabetic vascular disease
Vigili de Kreutzenberg, Saula;Giannella, Alessandra;Ceolotto, Giulio;Faggin, Elisabetta;Cappellari, Roberta;Mazzucato, Marta;Fraccaro, Chiara;Tarantini, Giuseppe;Avogaro, Angelo;Fadini, Gian Paolo
2022
Abstract
Ectopic calcification is a typical feature of diabetic vascular disease and resembles an accelerated ageing phenotype. We previously found an excess of myeloid calcifying cells in diabetic individuals. We herein examined molecular and cellular pathways linking atherosclerotic calcification with calcification by myeloid cells in the diabetic milieu.
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