A straightforward synthetic route to a selection of new ferrocenyl complexes bearing different organopalladium fragments is reported. The target complexes were fully characterized by Nuclear Magnetic Resonance, High Resolution Mass Spectrometry, Infrared Spectroscopy, X-ray Diffraction, and electrochemical techniques. All compounds, with the exception of Pd(0)-olefin derivatives, showed excellent antitumor activity on ovarian cancer cells and, in the case of Pd (II)-allyl and Pd (II)-butadienyl complexes, a lower cytotoxicity towards normal cells.
Synthesis, characterization, and anticancer activity of ferrocenyl complexes bearing different organopalladium fragments
Scattolin T.;Moretto L. M.;
2022
Abstract
A straightforward synthetic route to a selection of new ferrocenyl complexes bearing different organopalladium fragments is reported. The target complexes were fully characterized by Nuclear Magnetic Resonance, High Resolution Mass Spectrometry, Infrared Spectroscopy, X-ray Diffraction, and electrochemical techniques. All compounds, with the exception of Pd(0)-olefin derivatives, showed excellent antitumor activity on ovarian cancer cells and, in the case of Pd (II)-allyl and Pd (II)-butadienyl complexes, a lower cytotoxicity towards normal cells.
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