Studio prospettico su pazienti affette da connettivite indifferenziata in gravidanza;confronto con Lupus Eritematoso e Sindrome di Sjogren.

Undifferentiated connective tissue disease (UCTD) is a term used to identify a group of patient that while presenting common symptoms of systemic connective disease does not fulfil the criteria for a definite connective tissues disease. Arthralgias, Raynaud, mild fever and anti nuclear antibodies common features in UCTD patients. We have prospectively followed 50 pregnancies in 43 women with UCTD, 142 pregnancies in 111 women with SLE and 35 pregnancies in 26 women with primary Sjögren’s Syndrome. In UCTD women the mean gestational age at delivery was 38.6 weeks, the prevalence of pregnancy loss 2%, preterm birth 2%, cesarean sections 30.5%, Premature Rupture of Membrane (PROM) 0%, preeclampsia 0%, Intra Uterine Growth Retardation (IUGR) 8.2% and newborns Small for Gestational Age (SGA) 12.2%; average weight at birth was 3062.5 g. In SLE group the mean gestational age at delivery was 37.8 weeks, prevalence of pregnancy loss 14.7% (p < 0.005 vs UCTD), preterm birth 22.5%, cesarean sections 61.7%, PROM 8%, preeclampsia 4.2%, IUGR 1.7% and SGA 12.1%; average weight at birth was 2876.8 g (p < 0.05 vs UCTD). In women with Sjögren syndrome the mean gestational age at delivery was 38.5 weeks, prevalence of pregnancy loss 8.6%, preterm birth 13.9%, cesarean sections 29.4%, PROM 3.1%, preeclampsia 0%, IUGR 3.1% and SGA 6.3%. Conclusion: the general outcome of UCTD pregnancies is similar to that observed in women with primary Sjögren’s syndrome, and better than in SLE women. No patients evolved into a definite CTD, nor required an important modification of therapy during and after pregnancy. The general outcome of these pregnancies is now excellent, if prospectively followed by multidisciplinary teams with great experience in this field.