Alternative Technetium-99m production via 100Mo(p,2n)99mTc reaction route using medical cyclotrons, is reliable and relatively cost-effective1. However, it was found that the 99mTc thus produced contains small quantities of several 9xTc radioisotopes (93mTc, 93Tc, 94Tc, 94mTc, 95Tc, 95mTc 96Tc and 97mTc)2. The aim of this work was to estimate the effective dose-increase (DI) due to the contribution of 9xTc contaminants, after intravenous injection of four radiopharmaceuticals prepared with cyclotron-produced 99mTc (CP-99mTc) using 99.05% 100Mo-enriched molybdenum metallic targets.
Effective dose increase of cyclotron-produced 99mTc labelled radiopharmaceuticals
De Nardo L;Bello M;Paiusco M;Uzunov N;Esposito J;Rosato A
2020
Abstract
Alternative Technetium-99m production via 100Mo(p,2n)99mTc reaction route using medical cyclotrons, is reliable and relatively cost-effective1. However, it was found that the 99mTc thus produced contains small quantities of several 9xTc radioisotopes (93mTc, 93Tc, 94Tc, 94mTc, 95Tc, 95mTc 96Tc and 97mTc)2. The aim of this work was to estimate the effective dose-increase (DI) due to the contribution of 9xTc contaminants, after intravenous injection of four radiopharmaceuticals prepared with cyclotron-produced 99mTc (CP-99mTc) using 99.05% 100Mo-enriched molybdenum metallic targets.
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