A crucial amplificatory event in several apoptotic cascades is the complete release of cytochrome c from mitochondria. This is accomplished by the activation of multidomain proapoptotic members of the Bcl-2 family and accompanied by changes in the internal structure of mitochondria, a process known as cristae remodelling, and by mitochondrial fragmentation. Here we illustrate the role of dynamin-related proteins controlling mitochondrial morphology in the regulation of cristae remodelling, organelle fragmentation, cytochrome c release, apoptosis and genetic diseases like dominant optic atrophy; and discuss the controversies on their functional role in apoptosis, with an outlook on the possible exploitation of the inhibition of these proteins in cancer chemotherapy.
Cristae remodeling and mitochondrial fragmentation: A checkpoint for cytochrome c release and apoptosis?
Scorrano L.
2010
Abstract
A crucial amplificatory event in several apoptotic cascades is the complete release of cytochrome c from mitochondria. This is accomplished by the activation of multidomain proapoptotic members of the Bcl-2 family and accompanied by changes in the internal structure of mitochondria, a process known as cristae remodelling, and by mitochondrial fragmentation. Here we illustrate the role of dynamin-related proteins controlling mitochondrial morphology in the regulation of cristae remodelling, organelle fragmentation, cytochrome c release, apoptosis and genetic diseases like dominant optic atrophy; and discuss the controversies on their functional role in apoptosis, with an outlook on the possible exploitation of the inhibition of these proteins in cancer chemotherapy.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
