The endothelial glycocalyx, the gel layer covering the endothelium, is composed of gly-cosaminoglycans, proteoglycans, and adsorbed plasma proteins. This structure modulates vessels’ mechanotransduction, vascular permeability, and leukocyte adhesion. Thus, it regulates several physiological and pathological events. In the present review, we described the mechanisms that disturb glycocalyx stability such as reactive oxygen species, matrix metalloproteinases, and hepara-nase. We then focused our attention on the role of glycocalyx degradation in the induction of profi-brotic events and on the possible pharmacological strategies to preserve this delicate structure.

Endothelial glycocalyx as a regulator of fibrotic processes

Masola V.;Onisto M.
;
2021

Abstract

The endothelial glycocalyx, the gel layer covering the endothelium, is composed of gly-cosaminoglycans, proteoglycans, and adsorbed plasma proteins. This structure modulates vessels’ mechanotransduction, vascular permeability, and leukocyte adhesion. Thus, it regulates several physiological and pathological events. In the present review, we described the mechanisms that disturb glycocalyx stability such as reactive oxygen species, matrix metalloproteinases, and hepara-nase. We then focused our attention on the role of glycocalyx degradation in the induction of profi-brotic events and on the possible pharmacological strategies to preserve this delicate structure.
File in questo prodotto:
File Dimensione Formato  
endotelio.pdf

accesso aperto

Tipologia: Published (publisher's version)
Licenza: Creative commons
Dimensione 8.78 MB
Formato Adobe PDF
8.78 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/3393035
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 26
  • ???jsp.display-item.citation.isi??? 22
  • OpenAlex ND
social impact