Anastasia et al. characterize the contact established by a curved wrapping-type of rough ER (wrappER) with mitochondria and discover that this inter-organellar association is dynamic, regulated by lipid fluxes, and necessary for correct hepatic synthesis and secretion of very-low-density lipoproteins.
Mitochondria-rough-ER contacts in the liver regulate systemic lipid homeostasis
Anastasia I.;Ilacqua N.;Caicci F.;Valle G.;Giacomello M.;Scorrano L.;Pellegrini L.
2021
Abstract
Anastasia et al. characterize the contact established by a curved wrapping-type of rough ER (wrappER) with mitochondria and discover that this inter-organellar association is dynamic, regulated by lipid fluxes, and necessary for correct hepatic synthesis and secretion of very-low-density lipoproteins.
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