The nociceptin (NC)/orphanin FQ analog, [Arg(14), Lys(15)]NC, has been recently demonstrated to behave as a potent agonist at the human recombinant NC receptors (OP4). In this study, we evaluated the pharmacological profile of [Arg(14), Lys(15)]NC in vitro on the native OP4 receptors expressed in isolated tissues and in vivo in the locomotor activity and the tail-withdrawal assays in mice.
[Arg(14), Lys(15)]nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies
CALO', Girolamo
2002
Abstract
The nociceptin (NC)/orphanin FQ analog, [Arg(14), Lys(15)]NC, has been recently demonstrated to behave as a potent agonist at the human recombinant NC receptors (OP4). In this study, we evaluated the pharmacological profile of [Arg(14), Lys(15)]NC in vitro on the native OP4 receptors expressed in isolated tissues and in vivo in the locomotor activity and the tail-withdrawal assays in mice.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
