Immune thrombocytopenia (ITP) is an acquired disorder, characterized by immune-mediated platelet destruction. The spleen plays a key pathogenic role in ITP and splenectomy is a valuable second-line therapy for this disease. Little is known on ITP spleen histology and response to splenectomy is unpredictable. This study aims to characterize ITP spleen histology and assess possible predictors of splenectomy outcome.
Histology of the spleen in Immune Thrombocytopenia: clinical-pathological characterization and prognostic implications
Pizzi, Marco;Friziero, Alberto;Vianello, Fabrizio;Binotto, Gianni;Da Dalt, Gianfranco;Fassan, Matteo;Sbaraglia, Marta;Sperti, Cosimo;Baldan, Nicola;D'Amore, Fabio;Bertozzi, Irene;Sefora Pierobon, Elisa;Moletta, Lucia;Capovilla, Giovanni;Grego, Andrea;Fabris, Fabrizio;Merigliano, Stefano;Dei Tos, Angelo Paolo
2021
Abstract
Immune thrombocytopenia (ITP) is an acquired disorder, characterized by immune-mediated platelet destruction. The spleen plays a key pathogenic role in ITP and splenectomy is a valuable second-line therapy for this disease. Little is known on ITP spleen histology and response to splenectomy is unpredictable. This study aims to characterize ITP spleen histology and assess possible predictors of splenectomy outcome.
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