Kirsten rat sarcoma viral oncogene (KRAS) G12C was identified to be a drug target and a predictor of response to the novel AMG510 drug. We showed that KRAS G12C-mutated colorectal cancer has specific clinicopathologic features and worse outcome compared to other KRAS-mutated cases. The knowledge of such distinctive traits of KRAS G12C mutations might be crucial to future translational research studies and clinical trial design.
KRAS G12C Metastatic Colorectal Cancer: Specific Features of a New Emerging Target Population
Schirripa M.;Rossini D.;Businello G.;Pietrantonio F.;Bergamo F.;Dei Tos A. P.;Fassan M.;Loupakis F.
2020
Abstract
Kirsten rat sarcoma viral oncogene (KRAS) G12C was identified to be a drug target and a predictor of response to the novel AMG510 drug. We showed that KRAS G12C-mutated colorectal cancer has specific clinicopathologic features and worse outcome compared to other KRAS-mutated cases. The knowledge of such distinctive traits of KRAS G12C mutations might be crucial to future translational research studies and clinical trial design.
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