C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging

Background. Oxidation and inflammation are linked processes playing an important role in the development and progression of coronary artery disease (CAD). The relation between oxidation and inflammation markers with myocardial ischemia is still controversial. We assessed the association between paraoxonase (PON) polymorphisms (rs854560, rs662, rs7493) and high sensitivity C-reactive protein levels with stress-induced ischemia in patients with suspected CAD. Materials and methods. Patients (n = 203; 78 men; mean age 59 ± 10 years), with suspected CAD underwent on the same day stress/rest Tc-99m sestamibi cardiac single-photon emission computed tomography and venous blood samples collection, to assess PON polymorphisms, lipid profile and high sensitivity C-reactive protein levels. Results. At cardiac tomography, 43 (21%) patients had stress-induced myocardial ischemia and 160 (79%) did not. At logistic regression analysis, diabetes (p < 0.005), sex (p = 0.020) and high-density lipoprotei...