Delta hemoglobin (Delta Hb) is defined as the difference between the preoperative Hb and the lowest post-operative Hb level. We sought to define the impact of Delta Hb relative to nadir Hb levels on the likelihood of transfusion, as well as characterize the impact of Delta Hb and nadir Hb on morbidity among a large cohort of patients undergoing complex hepatopancreatobiliary (HPB) surgery. Patients who underwent pancreatic or hepatic resection between January 1, 2009 and June 30, 2015 at Johns Hopkins Hospital were identified. Data on the perioperative Delta Hb, nadir Hb, as well as blood utilization were obtained and analyzed. Multivariable logistic regression models were used to identify the factors associated with Delta Hb and the impact of Delta Hb on perioperative morbidity. A Bayesian model was used to evaluate the correlation of Delta Hb and nadir Hb with the likelihood of transfusion, as well as the impact on morbidity. A total of 4363 patients who underwent hepatobiliary (n = 2200, 50.4 %) or pancreatic (n = 2163, 49.6 %) surgery were identified. More than one quarter of patients received at least one unit of packed red blood cells (PRBC) (n = 1187, 27.2 %). The median nadir Hb was 9.2 (IQR 7.9-10.5) g/dL resulting in an average Delta Hb of 3.4 mg/dL (IQR 2.2-4.7) corresponding to 26.3 %. Both Delta Hb and nadir Hb strongly influenced provider behavior with regards to use of transfusion. Among patients with the same nadir Hb, Delta Hb was strongly associated with use of transfusion; among patients who had a nadir Hb aecurrency sign6 g/dL, the use of transfusion was only 17.9 % when the Delta Hb = 10 % versus 49.1 and 80.9 % when the Delta Hb was 30 or 50 %, respectively. Perioperative complications occurred in 584 patients (13.4 %) and were more common among patients with a higher value of Delta Hb, as well as patients who received PRBC (both P < 0.001). The combination of the Hb trigger with Delta Hb was associated with transfusion practices among providers. Larger Delta Hb values, as well as receipt of transfusion, were strongly associated with risk of perioperative complication following HPB surgery.
Impact of Delta Hemoglobin on Provider Transfusion Practices and Post-operative Morbidity Among Patients Undergoing Liver and Pancreatic Surgery
Spolverato Gaya;
2016
Abstract
Delta hemoglobin (Delta Hb) is defined as the difference between the preoperative Hb and the lowest post-operative Hb level. We sought to define the impact of Delta Hb relative to nadir Hb levels on the likelihood of transfusion, as well as characterize the impact of Delta Hb and nadir Hb on morbidity among a large cohort of patients undergoing complex hepatopancreatobiliary (HPB) surgery. Patients who underwent pancreatic or hepatic resection between January 1, 2009 and June 30, 2015 at Johns Hopkins Hospital were identified. Data on the perioperative Delta Hb, nadir Hb, as well as blood utilization were obtained and analyzed. Multivariable logistic regression models were used to identify the factors associated with Delta Hb and the impact of Delta Hb on perioperative morbidity. A Bayesian model was used to evaluate the correlation of Delta Hb and nadir Hb with the likelihood of transfusion, as well as the impact on morbidity. A total of 4363 patients who underwent hepatobiliary (n = 2200, 50.4 %) or pancreatic (n = 2163, 49.6 %) surgery were identified. More than one quarter of patients received at least one unit of packed red blood cells (PRBC) (n = 1187, 27.2 %). The median nadir Hb was 9.2 (IQR 7.9-10.5) g/dL resulting in an average Delta Hb of 3.4 mg/dL (IQR 2.2-4.7) corresponding to 26.3 %. Both Delta Hb and nadir Hb strongly influenced provider behavior with regards to use of transfusion. Among patients with the same nadir Hb, Delta Hb was strongly associated with use of transfusion; among patients who had a nadir Hb aecurrency sign6 g/dL, the use of transfusion was only 17.9 % when the Delta Hb = 10 % versus 49.1 and 80.9 % when the Delta Hb was 30 or 50 %, respectively. Perioperative complications occurred in 584 patients (13.4 %) and were more common among patients with a higher value of Delta Hb, as well as patients who received PRBC (both P < 0.001). The combination of the Hb trigger with Delta Hb was associated with transfusion practices among providers. Larger Delta Hb values, as well as receipt of transfusion, were strongly associated with risk of perioperative complication following HPB surgery.
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