A previous trial failed to demonstrate the superiority of a demographic-genetic algorithm in predicting warfarin (W) dose over a standard clinical approach. The purpose of the present study is to re-analyse the results in subgroups of patients with differing baseline sensitivity to W, integrated with additional pharmacokinetic data.
Pharmacokinetic and pharmacodynamic re-evaluation of a genetic-guided warfarin trial
Zambon, Carlo Federico;Pengo, Vittorio;Moz, Stefania;Bozzato, Dania;Fogar, Paola;Padoan, Andrea;Plebani, Mario;GROPPA, FRANCESCA;De Rosa, Giovanni;Padrini, Roberto
2018
Abstract
A previous trial failed to demonstrate the superiority of a demographic-genetic algorithm in predicting warfarin (W) dose over a standard clinical approach. The purpose of the present study is to re-analyse the results in subgroups of patients with differing baseline sensitivity to W, integrated with additional pharmacokinetic data.File in questo prodotto:
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