Toll-like receptor 4 (TLR4) plays a key role in the induction of inflammatory responses both in peripheral organs and the CNS. Curcumin exerts anti-inflammatory functions by interfering with LPS-induced TLR4-myeloid differentiation protein-2 (MD-2) dimerization and suppressing pro-inflammatory mediator release. However, the inhibitory mechanism of curcumin remains to be defined.
Phenolic 1,3-diketones attenuate lipopolysaccharide-induced inflammatory response by an alternative magnesium-mediated mechanism
ZUSSO, MORENA;MERCANTI, GIULIA;PAGETTA, ANDREA;MARINELLI, CARLA;BRUN, PAOLA;RAGAZZI, EUGENIO;GIUSTI, PIETRO;MORO, STEFANO
2017
Abstract
Toll-like receptor 4 (TLR4) plays a key role in the induction of inflammatory responses both in peripheral organs and the CNS. Curcumin exerts anti-inflammatory functions by interfering with LPS-induced TLR4-myeloid differentiation protein-2 (MD-2) dimerization and suppressing pro-inflammatory mediator release. However, the inhibitory mechanism of curcumin remains to be defined.
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