Our evidences of Hypoxia reporter response in polg morphants and in embryos treated with OXPHOS complexes inhibitors suggest the existence of cross-talk mechanisms sensing mitochondrial dysfunction and acting on Hypoxia signaling.
Mitochondrial DNA depletion and OXPHOS complex impairment modify Hypoxia signaling pathway activity in zebrafish
MARTORANO, LAURA;TISO, NATASCIA;BUSOLIN, GIORGIA;EK, OLIVIER FREDERIC D;FACCHINELLO, NICOLA;VETTORI, ANDREA;ARGENTON, FRANCESCO
2016
Abstract
Our evidences of Hypoxia reporter response in polg morphants and in embryos treated with OXPHOS complexes inhibitors suggest the existence of cross-talk mechanisms sensing mitochondrial dysfunction and acting on Hypoxia signaling.
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