The lack of positive costimulatory molecules represents one of the mechanisms by which tumor cells evade immune surveillance. Promoter hypermethylation plays a major role in cancer development through transcriptional silencing of critical genes. The aim of this study was to examine the expression of the costimulatory molecule CD80 in relationship with genomic methylation in non-inflammatory colon carcinogenesis.
CD80 down-regulation is associated to aberrant DNA methylation in non-inflammatory colon carcinogenesis
SCARPA, MARCO;SCARPA, MELANIA;CASTAGLIUOLO, IGNAZIO;ERROI, FRANCESCA;BASATO, SILVIA;BRUN, PAOLA;ANGRIMAN, IMERIO;CASTORO, CARLO
2016
Abstract
The lack of positive costimulatory molecules represents one of the mechanisms by which tumor cells evade immune surveillance. Promoter hypermethylation plays a major role in cancer development through transcriptional silencing of critical genes. The aim of this study was to examine the expression of the costimulatory molecule CD80 in relationship with genomic methylation in non-inflammatory colon carcinogenesis.
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