Ionic platinum(II) complexes [PtCl(PPh3)(L Lambda L)][BF4] {L Lambda L= 2,2'-bipyridyl (1) 1,10-phenanthroline (2)} and [PtCl(PPh3)(L)(2)][BF4] {L = pyridine (3), dimethyl sulfoxide (4)} were synthesized by dehalogenation of cis-[PtCl2(PPh3)(NCMe)], followed by reaction with the suitable ligand. Chelating nitrogen ligands L Lambda L afforded single products, which were structurally characterized. In the other cases mixtures of geometric (L = pyridine) and/or coordination (L = dimethyl sulfoxide) isomers were observed in solution. In these cases the structures of the less soluble isomers were obtained via single crystal X-ray diffraction. All the complexes were tested in vitro for their antiproliferative activity on three human tumor cell lines: MSTO-211H, HeLa and HepG2.
Synthesis and antiproliferative activity of ionic platinum(II) triphenylphosphino complexes
GARCIA ARGAEZ, AIDA NELLY;DALLA VIA, LISA
2016
Abstract
Ionic platinum(II) complexes [PtCl(PPh3)(L Lambda L)][BF4] {L Lambda L= 2,2'-bipyridyl (1) 1,10-phenanthroline (2)} and [PtCl(PPh3)(L)(2)][BF4] {L = pyridine (3), dimethyl sulfoxide (4)} were synthesized by dehalogenation of cis-[PtCl2(PPh3)(NCMe)], followed by reaction with the suitable ligand. Chelating nitrogen ligands L Lambda L afforded single products, which were structurally characterized. In the other cases mixtures of geometric (L = pyridine) and/or coordination (L = dimethyl sulfoxide) isomers were observed in solution. In these cases the structures of the less soluble isomers were obtained via single crystal X-ray diffraction. All the complexes were tested in vitro for their antiproliferative activity on three human tumor cell lines: MSTO-211H, HeLa and HepG2.
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