Response to comment on: Tessari et al. Roles of insulin, age, and asymmetric dimethylarginine on nitric oxide synthesis in vivo. Diabetes 2013;62:2699-2708

Ours as well as other recently published articles challenge the somehow dogmatic concept about the existence of a uniform and comprehensive state of “insulin resistance,” a condition that should be considered multifaceted, and not defined just on the basis of the reduced insulin-mediated glucose disposal. This more complex view may have relevant consequences not only from a mechanistic but also from a therapeutic standpoint.