Asymmetric dimethylarginine (ADMA) competitively inhibits nitric oxide synthase (NOS). Its levels in specimens from murine models and asthmatic patients are related to inflammation and oxidative stress. Patients with cystic fibrosis(CF) reportedly have higher arginase activity, lower NO production and NOS expression than healthy controls.
Asymmetric dimethylarginine and related metabolites in exhaled breath condensate of children with cystic fibrosis
DA DALT, LIVIANA;PIRILLO, PAOLA;PERILONGO, GIORGIO;BARALDI, EUGENIO
2016
Abstract
Asymmetric dimethylarginine (ADMA) competitively inhibits nitric oxide synthase (NOS). Its levels in specimens from murine models and asthmatic patients are related to inflammation and oxidative stress. Patients with cystic fibrosis(CF) reportedly have higher arginase activity, lower NO production and NOS expression than healthy controls.
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