In this issue of Structure, Pumroy and colleagues have solved the crystal structure of the influenza virus polymerase PB2 C-terminal domain complexed with different Importin αs. Combining molecular dynamics with structural and biochemical data, the so-far elusive basis for selectivity of binding to distinct different importin αs is beginning to become accessible.
Basis of cargo recognition by importin αs: the power of structure.
ALVISI, GUALTIERO;
2015
Abstract
In this issue of Structure, Pumroy and colleagues have solved the crystal structure of the influenza virus polymerase PB2 C-terminal domain complexed with different Importin αs. Combining molecular dynamics with structural and biochemical data, the so-far elusive basis for selectivity of binding to distinct different importin αs is beginning to become accessible.
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