GSK-3isamultifunctionalkinasethatislocatedinthecytosol,nucleus,andmitochondriaofallcelltypes,anditisinvolvedinthepathogenesisofavarietyofdiseases.Incancer,GSK-3modulatestheresponseofthecelldeathmachinerytostressstimuli,includingchemotherapeutics.Mitochondriaareattheheartoftheintegrationbetweensurvivalandnoxioussignals;therefore,modulationofthemitochondrialfunctionscarriedoutbyGSK-3isprofoundlyinvolvedintheapoptosisescapecapabilitiesthathallmarkneoplasms.Thisreviewbrieflycoversthemechanisticinteractionsamongoncogenickinasepathways,GSK-3activityandsubsequentmodulationofmitochondrialfunctionsthatshapethepro-survivalphenotypeofcancercells,suchascontrolofredoxhomeostasisandinhibitionofthemitochondrialpermeabilitytransitionpore.
GSK-3 and mitochondria in cancer cells
CHIARA, FEDERICA;RASOLA, ANDREA
2013
Abstract
GSK-3isamultifunctionalkinasethatislocatedinthecytosol,nucleus,andmitochondriaofallcelltypes,anditisinvolvedinthepathogenesisofavarietyofdiseases.Incancer,GSK-3modulatestheresponseofthecelldeathmachinerytostressstimuli,includingchemotherapeutics.Mitochondriaareattheheartoftheintegrationbetweensurvivalandnoxioussignals;therefore,modulationofthemitochondrialfunctionscarriedoutbyGSK-3isprofoundlyinvolvedintheapoptosisescapecapabilitiesthathallmarkneoplasms.Thisreviewbrieflycoversthemechanisticinteractionsamongoncogenickinasepathways,GSK-3activityandsubsequentmodulationofmitochondrialfunctionsthatshapethepro-survivalphenotypeofcancercells,suchascontrolofredoxhomeostasisandinhibitionofthemitochondrialpermeabilitytransitionpore.| File | Dimensione | Formato | |
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