Complexation of Al(III) with hydroxypyridine(di)carboxylic acids as new possible chelating agents in neurodegenerative diseases

Although aluminium is the most abundant element in the earth’s crust, mostly found in the form of stable chemical compound therefore nearly unavailable for the living organism and has not become a biological by essential element. Nowadays through the human activity our body are exposed several soluable aluminium salt. The aluminium can be transported by transferrin to several places in the organism where can accumulate and cause biological dysfunctions. In many cases the neurodegenerative disorders like Alzheimer’s disease (AD) is associated with aluminium toxicity. Although its role is not clear several study reported aluminium deposits in the AD brain. The chelation therapy has been shown effective to mobilize the aluminium from the deposit. The two well established chelators (desferal and deferiprone) have several drawbacks. We proposed some hydroxipyridine(di)carboxylic acids as a potential chelating agents for Al. In the present poster we show the complexation properties of these ligands with Al(III).