A non-peptide oligo-guanidyl derivative was prepared and investigated as cell penetration enhancer for bioactive macromolecules and colloidal drug delivery systems. The cell penetration properties of the multi-armed oligo-arginyl derivative was evaluated using fluorescein-labelled bovine serum albumin as large size hydrophilic cargo molecule on two different cell lines by fluorescence spectroscopy, flow cytometry and confocal microscopy.
Novel Oligo-guanidyl Derivatives As Cell Penetrating Tools For Intracellular Delivery Of Therapeutic Supramolecular Systems.
BERSANI, SARA;SALMASO, STEFANO;F. Mastrotto;CALICETI, PAOLO
2011
Abstract
A non-peptide oligo-guanidyl derivative was prepared and investigated as cell penetration enhancer for bioactive macromolecules and colloidal drug delivery systems. The cell penetration properties of the multi-armed oligo-arginyl derivative was evaluated using fluorescein-labelled bovine serum albumin as large size hydrophilic cargo molecule on two different cell lines by fluorescence spectroscopy, flow cytometry and confocal microscopy.
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